{"created":"2025-02-18T09:59:14.188593+00:00","id":2005027,"links":{},"metadata":{"_buckets":{"deposit":"e04d1aca-8c65-45cb-9d59-08ff7612eaf6"},"_deposit":{"created_by":41,"id":"2005027","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2005027"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02005027","sets":["1730444908512:1730444915582"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection","subitem_title_language":"en"},{"subitem_title":"TIMP-1 c.T372C遺伝子多型による急性大動脈解離の予測可能性","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naychov, Zheko Dimitrov","creatorNameLang":"en"}],"familyNames":[{"familyName":"Naychov","familyNameLang":"en"}],"givenNames":[{"givenName":"Zheko Dimitrov","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Aortic dissection","subitem_subject_scheme":"Other"},{"subitem_subject":"SNP","subitem_subject_scheme":"Other"},{"subitem_subject":"TIMP-1","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"While single nucleotide polymorphisms (SNP) have been extensively researched in atherosclerotic aortic aneurysms, there are too few data about acute aortic dissection (AAD). The matrix metalloproteinase regulation system has shown a high biological relevance to the development of aortic aneurysms and AAD. The TIMP-1 c.T372C (rs4898, nt+434) SNP was previously associated with the onset of abdominal aortic and other aneurysms. Therefore, we chose this SNP to search for a connection with AAD and to find its place among the other risk factors. 115 patients with AAD were studied for their TIMP-1 c.T372C genotype by means of conventional restrictase analysis. To confirm the biological relevance of our findings, immunohistochemistry for TIMP-1 was performed on tissue samples from the same patients with AAD and compared with a control group of 23 autopsy cases. The TIMP-1 c.T372C showed a significant difference in allele frequency in the AAD patients compared to the general population (p < 0.0001 for both sexes). This genotype did not show any association with any other co-morbid condition, nor with age. The immunohistochemistry results also showed significantly lower TIMP-1 expression in the dissected aortas. The C allele of TIMP-1 c.T372C shows a strong association with the onset of AAD.","subitem_description_language":"en"}]},"item_1617186660861":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-25","subitem_date_issued_type":"Created"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187087799":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第6245号"}]},"item_1617187112279":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_1617187136212":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"2013-09-25"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Zheko Dimirtov Naychov, Eiso Hiyama, Naomichi Uchida, Koji Arihiro, Masataka Nagao, Shinya Takahashi, Konstantin Vassilev Delchev and Taijiro Sueda; TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection; Hiroshima J. Med. Sci. Vol.62, No.2, 31-37, June, 2013"}],"subitem_relation_type":"references"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-25"}],"displaytype":"simple","filename":"k6245_3.pdf","filesize":[{"value":"399.0 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2005027/files/k6245_3.pdf"},"version_id":"8eb3433f-09a3-472a-822e-4bc9a7f372ce"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-25"}],"displaytype":"simple","filename":"k6245_1.pdf","filesize":[{"value":"178.3 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005027/files/k6245_1.pdf"},"version_id":"64e63393-eb98-456a-b97e-9ea0a7059c3c"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-25"}],"displaytype":"simple","filename":"k6245_2.pdf","filesize":[{"value":"165.8 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005027/files/k6245_2.pdf"},"version_id":"628e54e4-0181-44f2-b0d9-7c6f74112d92"}]},"item_1617944105607":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"広島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"15401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]},{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Hiroshima University"}]}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"36322"},"item_title":"TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection","item_type_id":"40003","owner":"41","path":["1730444915582"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-11-25"},"publish_date":"2014-11-25","publish_status":"0","recid":"2005027","relation_version_is_last":true,"title":["TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-20T07:21:45.049386+00:00"}