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Genetic alterations of Wnt signal components in cancer cells
https://hiroshima.repo.nii.ac.jp/records/2000946
https://hiroshima.repo.nii.ac.jp/records/2000946d0057eaa-990c-413f-b16c-0006da341d18
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Symp-Edu-Sci_101-106.pdf (862.4 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Genetic alterations of Wnt signal components in cancer cells | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Kikuchi, Akira
× Kikuchi, Akira
× Kinshasa, S.
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Wnt | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | β-catenin | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | APC | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Axin | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Tcf | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | The genetics of development and cancer have converged in the identification of intra- and extra-cellular signaling pathways that are aberrantly regulated in cancer and are also central to embryonic patterning. The Wnt signaling pathway has provided an outstanding example of this. The genes for β-catenin, APC, and Axin in the Wnt signaling pathway are often mutated in human cancers. In all such cases, the common denominator is the accumulation of cytosolic and nuclear β-catenin and the activation of transcriptional factor Tcf/Lef. The resulting gene expression profile should provide a significant clue as to cancers carrying defects in the Wnt signaling pathway. In this review, the regulation of the β-catenin stability by Axin and APC, and their genetic alterations in human cancers are described. | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||||||
| 資源タイプ | conference paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連情報 | ||||||||||
| 関連タイプ | isPartOf | |||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | http://ir.lib.hiroshima-u.ac.jp/meta-bin/mt-pdetail.cgi?smode=1&edm=0&tlang=1&cd=00014842 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 101 | |||||||||
| 書誌情報 |
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry p. 101-106, 発行日 2006-01-08 |
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| 旧ID | 102 | |||||||||
