{"created":"2025-02-18T01:40:41.333474+00:00","id":2000946,"links":{},"metadata":{"_buckets":{"deposit":"06dfbb70-9ecd-474e-9739-1abdcafd5d16"},"_deposit":{"created_by":41,"id":"2000946","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2000946"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02000946","sets":["1730444917621"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Genetic alterations of Wnt signal components in cancer cells","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kikuchi, Akira","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kikuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"Akira","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kinshasa, S.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kinshasa","familyNameLang":"en"}],"givenNames":[{"givenName":"S.","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Wnt","subitem_subject_scheme":"Other"},{"subitem_subject":"β-catenin","subitem_subject_scheme":"Other"},{"subitem_subject":"APC","subitem_subject_scheme":"Other"},{"subitem_subject":"Axin","subitem_subject_scheme":"Other"},{"subitem_subject":"Tcf","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The genetics of development and cancer have converged in the identification of intra- and extra-cellular signaling pathways that are aberrantly regulated in cancer and are also central to embryonic patterning. The Wnt signaling pathway has provided an outstanding example of this. The genes for β-catenin, APC, and Axin in the Wnt signaling pathway are often mutated in human cancers. In all such cases, the common denominator is the accumulation of cytosolic and nuclear β-catenin and the activation of transcriptional factor Tcf/Lef. The resulting gene expression profile should provide a significant clue as to cancers carrying defects in the Wnt signaling pathway. In this review, the regulation of the β-catenin stability by Axin and APC, and their genetic alterations in human cancers are described.","subitem_description_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"101"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-01-08","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"106","bibliographicPageStart":"101","bibliographic_titles":[{"bibliographic_title":"Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry"},{"bibliographic_title":"Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isPartOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ir.lib.hiroshima-u.ac.jp/meta-bin/mt-pdetail.cgi?smode=1&edm=0&tlang=1&cd=00014842","subitem_relation_type_select":"URI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"Symp-Edu-Sci_101-106.pdf","filesize":[{"value":"862.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2000946/files/Symp-Edu-Sci_101-106.pdf"},"version_id":"d18840d6-e46d-4ddb-afd2-be9d3b3896c0"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"102"},"item_title":"Genetic alterations of Wnt signal components in cancer cells","item_type_id":"40003","owner":"41","path":["1730444917621"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2000946","relation_version_is_last":true,"title":["Genetic alterations of Wnt signal components in cancer cells"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-18T03:02:19.597454+00:00"}