| Item type |
デフォルト(1) |
| 公開日 |
2025-07-16 |
| タイトル |
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タイトル |
Reactions Driven by Primitive Nonbiological Polyesters |
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言語 |
en |
| 作成者 |
Poddar, Arunava
Satthiyasilan, Nirmell
Wang, Po-Hsiang
Chen, Chen
Yi, Ruiqin
Chandru, Kuhan
Jia, Tony Z.
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| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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言語 |
en |
|
権利情報 |
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Accounts of Chemical Research, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.accounts.4c00167 The full-text file will be made open to the public after 16 July 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving'. This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
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言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
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内容記述 |
All life on Earth is composed of cells, which are built from and run by biological reactions and structures. These reactions and structures are generally the result of action by cellular biomolecules, which are indispensable for the function and survival of all living organisms. Specifically, biological catalysis, namely by protein enzymes, but also by other biomolecules including nucleic acids, is an essential component of life. How the biomolecules themselves that perform biological catalysis came to exist in the first place is a major unanswered question that plagues researchers to this day, which is generally the focus of the origins of life (OoL) research field. Based on current knowledge, it is generally postulated that early Earth was full of a myriad of different chemicals, and that these chemicals reacted in specific ways that led to the emergence of biochemistry, cells, and later, life. In particular, a significant part of OoL research focuses on the synthesis, evolution, and function of biomolecules potentially present under early Earth conditions, as a way to understand their eventual transition into modern life. However, this narrative overlooks possibilities that other molecules contributed to the OoL, as while biomolecules that led to life were certainly present on early Earth, at the same time, other molecules that may not have strict, direct biological lineage were also widely and abundantly present. For example, hydroxy acids, although playing a role in metabolism or as parts of certain biological structures, are not generally considered to be as essential to modern biology as amino acids (a chemically similar monomer), and thus research in the OoL field tends to perhaps focus more on amino acids than hydroxy acids. However, their likely abundance on early Earth coupled with their ability to spontaneously condense into polymers (i.e., polyesters) make hydroxy acids, and their subsequent products, functions, and reactions, a reasonable target of investigation for prebiotic chemists. Whether “non-biological” hydroxy acids or polyesters can contribute to the emergence of life on early Earth is an inquiry that deserves attention within the OoL community, as this knowledge can also contribute to our understanding of the plausibility of extraterrestrial life that does not exactly use the biochemical set found in terrestrial organisms. While some demonstrations have been made with respect to compartment assembly, compartmentalization, and growth of primitive polyester-based systems, whether these “non-biological” polymers can contribute any catalytic function and/or drive primitive reactions is still an important step toward the development of early life. Here, we review research both from the OoL field as well as from industry and applied sciences regarding potential catalysis or reaction driven by “non-biological” polyesters in various forms: as linear polymers, as hyperbranched polyesters, and as membraneless microdroplets. |
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言語 |
en |
| 内容記述 |
|
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内容記述タイプ |
Other |
|
内容記述 |
K.C. and N.S are supported by the Fundamental Research Grant Scheme (FRGS/1/2021/STG04/UKM/02/1) provided by the Ministry of Higher Education (MoHE) Malaysia and Visitor Grant (ZF-2022-008). T.Z.J. is supported by a JSPS Grant-in-aid 21K14746, the Mizuho Foundation for the Promotion of Science, and the Assistant Staffing Program by the Work-Life Balance Support Unit, Diversity Promotion Office, Tokyo Institute of Technology. C.C. is supported by a RIKEN Special Postdoctoral Researchers (SPDR) fellowship. P.-H.W. is supported by the National Science and Technology Council of Taiwan (112-2628-E008-005). A.P. is an Erasmus Mundus grant holder of the EMJMD Environmental Contamination and Toxicology (ECT+, SGA 2019-1485). |
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言語 |
en |
| 出版者 |
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|
出版者 |
American Chemical Society |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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|
関連識別子 |
10.1021/acs.accounts.4c00167 |
| 助成情報 |
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助成機関識別子タイプ |
Crossref Funder |
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助成機関識別子タイプURI |
https://doi.org/10.13039/501100001691 |
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助成機関名 |
日本学術振興会 |
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言語 |
ja |
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|
助成機関名 |
Japan Society for the Promotion of Science |
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言語 |
en |
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研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21K14746/ |
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|
研究課題番号 |
21K14746 |
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研究課題名 |
Biomolecule compartmentalization by phase separated protocells |
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言語 |
en |
| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0001-4842 |
| 書誌情報 |
en : Accounts of Chemical Research
巻 57,
号 15,
p. 2048-2057,
発行日 2024-07-16
|
acs.accounts_57-15_2048.docx (1.8 MB)
