| Item type |
デフォルト(1) |
| 公開日 |
2025-06-20 |
| タイトル |
|
|
タイトル |
Correlation Analysis Between Echinocytosis Stages and Blood Viscosity During Oxygenator Perfusion: An In Vitro Study |
|
言語 |
en |
| 作成者 |
Okahara, Shigeyuki
Miyamoto, Satoshi
Soh, Zu
Yoshino, Masaru
Takahashi, Hidenobu
Itoh, Hideshi
Tsuji, Toshio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is a pre-copyedited, author-produced version of an article accepted for publication in [ASAIO JOURNAL]. The published version of record [Okahara, Shigeyuki; Miyamoto, Satoshi; Soh, Zu; Yoshino, Masaru; Takahashi, Hidenobu; Itoh, Hideshi; Tsuji,Toshio.Title of the article.Correlation Analysis Between Echinocytosis Stages and Blood Viscosity During Oxygenator Perfusion: An In Vitro Study."ASAIO JOURNAL"2024.70(11): p 938-945] is available online at: [http://doi.org/10.1097/MAT.0000000000002214]. |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The study aimed to investigate the effect of red blood cell (RBC) morphology on oxygenator perfusion, focusing on stages of echinocytosis and their correlation with blood viscosity. A test circuit with an oxygenator and human RBC mixtures was used to induce changes in RBC shape by increasing sodium salicylate concentrations (0, 10, 20, 30, 60, and 120 mmol/L), while hematocrit, blood temperature, and anticoagulation were maintained. Blood viscosity was measured using a continuous blood viscosity monitoring system based on pressure-flow characteristics. Under a scanning electron microscope, the percentages of discocytes, echinocytes I–III, spheroechinocytes, and spherocytes were determined from approximately 400 cells per RBC sample. Early echinocytes, mainly discocytes and echinocytes I and II in the range of 0–30 mmol/L were predominant, resulting in a gradual increase in blood viscosity from 1.78 ± 0.12 to 1.94 ± 0.12 mPa s. At 60 mmol/L spherocytes emerged, and at 120 mmol/L, spheroidal RBCs constituted 50% of the population, and blood viscosity sharply rose to 2.50 ± 0.15 mPa s, indicating a 40% overall increase. In conclusion, the presence of spherocytes significantly increases blood viscosity, which may affect oxygenator perfusion. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work resulted from the use of research equipment shared under the MEXT Project for promoting public utilization of advanced research infrastructure (Program for advanced research equipment platforms), Grant Number JPMXS0450200322. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Wolters Kluwer Health, Inc. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1097/MAT.0000000000002214 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1058‑2916 |
| 書誌情報 |
en : ASAIO JOURNAL
巻 70,
号 11,
p. 938-945,
発行日 2024-04-18
|
AJ_70_11_938.docx (2.4 MB)
