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Management policy for postoperative acromegaly patients with normal IGF-1 and high GH levels on oral glucose tests
https://hiroshima.repo.nii.ac.jp/records/2040745
https://hiroshima.repo.nii.ac.jp/records/20407451545ef3c-6d1e-410d-9655-f74f2650113e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Pituitary_28_4.pdf (902 KB)
Download is available from 2025/12/26.
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| Item type | デフォルト(1) | |||||||||||||||||
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| 公開日 | 2025-06-17 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Management policy for postoperative acromegaly patients with normal IGF-1 and high GH levels on oral glucose tests | |||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 作成者 |
Kinoshita, Yasuyuki
× Kinoshita, Yasuyuki
× Taguchi, Akira
× Yamasaki, Fumiyuki
× Onishi, Shumpei
× Tominaga, Atsushi
× Horie, Nobutaka
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| アクセス権 | ||||||||||||||||||
| アクセス権 | embargoed access | |||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_f1cf | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s11102-024-01487-9 | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 権利情報 | This is not the published version. Please cite only the published version. | |||||||||||||||||
| 権利情報 | ||||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 権利情報 | この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Acromegaly | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Growth hormone | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Insulin-like growth factor-1 | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Discordance | |||||||||||||||||
| 主題 | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Discrepancy | |||||||||||||||||
| 内容記述 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Purpose Acromegaly patients occasionally achieve either of the remission criterion of IGF-1 or GH level postoperatively; however, treatment for patients with discordant IGF-1 and GH levels remains unclear. This study aimed to clarify the clinical courses and features of postoperative patients with normal IGF-1 and high GH levels and support their management. Methods Overall, 110 acromegaly patients underwent initial surgery and a 75-g oral glucose tolerance test (OGTT) 3 months postoperatively. Of the 110, 23 patients with normal IGF-1 and nadir GH levels of ≥ 0.4 µg/L on OGTT (high-GH group) were categorized into three subtypes based on their repeated examinations thereafter: late-remission type (nadir GH level on OGTT of < 0.4 µg/L later), recurrence type (elevated IGF-1 and GH levels later), and persistent type (normal IGF-1 levels and constantly high nadir GH levels on OGTTs). Results Proportion of patients in the high-GH group was 23.6%, and they were distributed as follows: late-remission type (n = 10), recurrence type (n = 5), and persistent type (n = 8). There were significantly more women (P = 0.0178) than men in the late-remission type, and patients in the persistent type had significantly larger tumors (P = 0.0110) and higher preoperative GH levels (P = 0.0018) than those that achieved complete remission 3 months postoperatively. Conclusion Careful monitoring without additional medications is recommended at first in acromegaly patients with normal IGF-1 and high GH levels considering the possibility of recurrence in the future. |
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| 言語 | en | |||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | Springer | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 日付 | ||||||||||||||||||
| 日付 | 2025-12-26 | |||||||||||||||||
| 日付タイプ | Available | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 出版タイプ | ||||||||||||||||||
| 出版タイプ | AM | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||||
| 関連情報 | ||||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | https://doi.org/10.1007/s11102-024-01487-9 | |||||||||||||||||
| 助成情報 | ||||||||||||||||||
| 助成機関識別子タイプ | Crossref Funder | |||||||||||||||||
| 助成機関識別子タイプURI | https://doi.org/10.13039/501100001691 | |||||||||||||||||
| 助成機関名 | 日本学術振興会 | |||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 助成機関名 | Japan Society for the Promotion of Science | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 研究課題番号URI | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06697/ | |||||||||||||||||
| 研究課題番号 | 23K06697 | |||||||||||||||||
| 研究課題名 | Pit-NETにおけるsmall RNAを用いた診断バイオマーカーの確立と核酸医薬への応用 | |||||||||||||||||
| 言語 | ja | |||||||||||||||||
| 書誌情報 |
en : Pituitary 巻 28, 号 4, p. none, ページ数 9, 発行日 2024-12-26 |
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| 言語 | en | |||||||||||||||||
| 値 | The full-text file will be made open to the public on 26 December 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving' | |||||||||||||||||
