| Item type |
デフォルト(1) |
| 公開日 |
2025-06-12 |
| タイトル |
|
|
タイトル |
Aged Garlic Extract Attenuates CaCl2-Induced Abdominal Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase 9 Expression in Macrophages |
|
言語 |
en |
| 作成者 |
Karasaki, Kohei
Ishida, Mari
Kokubo, Hiroki
Sakai, Chiemi
Kobayashi, Yusuke
Yoshizumi, Masao
|
| アクセス権 |
|
|
アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is the peer reviewed version of the following article: Kohei Karasaki, Mari Ishida, Hiroki Kokubo, Chiemi Sakai, Yusuke Kobayashi, Masao Yoshizumi, Molecular Nutrition & Food Research 2025, 69(9), e70028, which has been published in final form at https://doi.org/10.1002/mnfr.70028. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
abdominal aortic aneurysm |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
aged garlic extract |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inflammation |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
macrophage |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
matrix metalloproteinase |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Abdominal aortic aneurysm (AAA) is a local enlargement of the abdominal aorta with the risk of its fatal rupture. With lack of established medical treatments reducing the AAA growth, the development of treatment strategies for AAA is warranted. In this study, we examined whether aged garlic extract (AGE), which reportedly has vasoprotective effects, attenuates AAA formation in an animal model. AAAs were induced via CaCl2 application to the abdominal aortas of C57BL/6J mice. The intake of an AGE-containing diet attenuated the aortic dilatation after AAA induction. Histological analysis showed that the degradation of elastic fibers in AAAs was mild in mice fed AGE compared to that in control mice. In addition, the expression of matrix metalloproteinase 9 (MMP9), a proteolytic enzyme degrading aortic tissue, was decreased in AAAs from mice fed with AGE. In cultured macrophages, AGE significantly inhibited tumor necrosis factor (TNF)-α-induced Mmp9 mRNA expression. Furthermore, AGE attenuated TNF-α-induced extracellular signal-regulated kinase (ERK) phosphorylation and c-fos mRNA expression, suggesting the suppressive effect of AGE on ERK-c-Fos-MMP9 axis induced by TNF-α. The present findings indicate that AGE diminishes AAA formation by mitigating tissue destruction, highlighting the potential cardiovascular benefits of AGE intake. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This study was funded by the Wakunaga Pharmaceutical Co. Ltd. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Wiley |
|
言語 |
en |
| 日付 |
|
|
日付 |
2026-03-23 |
|
日付タイプ |
Available |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/mnfr.70028 |
| 書誌情報 |
en : Molecular Nutrition & Food Research
巻 69,
号 9,
p. e70028,
発行日 2025-03-23
|
| 備考 |
|
|
言語 |
en |
|
値 |
The full-text file will be made open to the public on 23 March 2026 in accordance with publisher's 'Terms and Conditions for Self-Archiving' |
MNFR_69_e70028.pdf (3.1 MB)
