| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Diagnostic Value of Fractional Anisotropy in Detecting Hippocampal Sclerosis: A Study on Intractable Mesial Temporal Lobe Epilepsy with Normal MRI |
|
言語 |
en |
| 作成者 |
Sukmaningtyas, Hermina
Pandelaki, Jacub
Astuti, Meira Dewi Kusuma
Fauziah, Diah
Riwanto, Ignatius
Muttaqin, Zainal
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2018 Hiroshima University Medical Press |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
intractable MTLE |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
normal MRI |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
DTI |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
fractional anisotropy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hippocampal sclerosis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Mesial |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Purpose: This study aimed to investigate whether Fractional Anisotropy (FA) is reliable in detecting hippocampal sclerosis on intractable Mesial Temporal Lobe Epilepsy (MTLE) with normal MRI as measured from the degree of of neuronal loss, gliosis and axonal sprouting. Method: Twenty-three MTLE patients underwent surgery and 10 healthy volunteers were involved in this study. The MTLE diagnosis was based on semiology and ictal EEG, while hippocampal sclerosis was diagnosed using standardized MRI, followed by DTI FA. Histopathological analysis of hippocampus was performed with NeuN, GFAP, and NPY staining to detect the neuronal loss, gliosis, and axonal sprouting. Correlation and Diagnostic test was done to asses of diagnostic value FA. Result: Ten MTLE patients showed normal MR, 4 with hippocampal sclerosis and 6 were with FCD. The value of FA was significantly lower compared with healthy subject. The cut-off point of FA in detecting hippocampal sclerosis was 0.17 (AUC=0.89). The sensitiviy, specificity, positive predictive value, and negative predictive value of FA were 81.8%, 72.3%, 64.3%, and 89.56% respectively. There was significantly correlation between FA with the degrees of neuronal loss and gliosis. The concurrence between FA with EEG 7 out of 10 patients. Conclusion: Fractional Anisotropy has a good diagnostic value in detecting hippocampal sclerosis on normal MRI patients. In addition, this technique also shows a moderate association with degrees of neuronal loss and gliosis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
191 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 67,
p. 191-198,
発行日 2018-05
|
| 旧ID |
45865 |
HiroshimaJMedSci_67s_191.pdf (467.5 KB)
