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  1. 広島大学の刊行物
  2. Hiroshima Journal of Medical Sciences
  3. 67巻

Diagnostic Value of Fractional Anisotropy in Detecting Hippocampal Sclerosis: A Study on Intractable Mesial Temporal Lobe Epilepsy with Normal MRI

https://hiroshima.repo.nii.ac.jp/records/2013786
https://hiroshima.repo.nii.ac.jp/records/2013786
0034af77-8eb2-4421-83db-1337552fd62e
名前 / ファイル ライセンス アクション
HiroshimaJMedSci_67s_191.pdf HiroshimaJMedSci_67s_191.pdf (467.5 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Diagnostic Value of Fractional Anisotropy in Detecting Hippocampal Sclerosis: A Study on Intractable Mesial Temporal Lobe Epilepsy with Normal MRI
言語 en
作成者 Sukmaningtyas, Hermina

× Sukmaningtyas, Hermina

en Sukmaningtyas, Hermina

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Pandelaki, Jacub

× Pandelaki, Jacub

en Pandelaki, Jacub

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Astuti, Meira Dewi Kusuma

× Astuti, Meira Dewi Kusuma

en Astuti, Meira Dewi Kusuma

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Fauziah, Diah

× Fauziah, Diah

en Fauziah, Diah

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Riwanto, Ignatius

× Riwanto, Ignatius

en Riwanto, Ignatius

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Muttaqin, Zainal

× Muttaqin, Zainal

en Muttaqin, Zainal

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2018 Hiroshima University Medical Press
主題
主題Scheme Other
主題 intractable MTLE
主題
主題Scheme Other
主題 normal MRI
主題
主題Scheme Other
主題 DTI
主題
主題Scheme Other
主題 fractional anisotropy
主題
主題Scheme Other
主題 hippocampal sclerosis
主題
主題Scheme Other
主題 Mesial
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Purpose: This study aimed to investigate whether Fractional Anisotropy (FA) is reliable in detecting hippocampal sclerosis on intractable Mesial Temporal Lobe Epilepsy (MTLE) with normal MRI as measured from the degree of of neuronal loss, gliosis and axonal sprouting. Method: Twenty-three MTLE patients underwent surgery and 10 healthy volunteers were involved in this study. The MTLE diagnosis was based on semiology and ictal EEG, while hippocampal sclerosis was diagnosed using standardized MRI, followed by DTI FA. Histopathological analysis of hippocampus was performed with NeuN, GFAP, and NPY staining to detect the neuronal loss, gliosis, and axonal sprouting. Correlation and Diagnostic test was done to asses of diagnostic value FA. Result: Ten MTLE patients showed normal MR, 4 with hippocampal sclerosis and 6 were with FCD. The value of FA was significantly lower compared with healthy subject. The cut-off point of FA in detecting hippocampal sclerosis was 0.17 (AUC=0.89). The sensitiviy, specificity, positive predictive value, and negative predictive value of FA were 81.8%, 72.3%, 64.3%, and 89.56% respectively. There was significantly correlation between FA with the degrees of neuronal loss and gliosis. The concurrence between FA with EEG 7 out of 10 patients. Conclusion: Fractional Anisotropy has a good diagnostic value in detecting hippocampal sclerosis on normal MRI patients. In addition, this technique also shows a moderate association with degrees of neuronal loss and gliosis.
言語 en
出版者
出版者 Hiroshima University Medical Press
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0018-2052
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA00664312
開始ページ
開始ページ 191
書誌情報 Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences

巻 67, p. 191-198, 発行日 2018-05
旧ID 45865
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