| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Polymorphism in 4'-UTR Region of PITX2 in Vertical Mandibular Symmetry |
|
言語 |
en |
| 作成者 |
Sofyanti, Ervina
Boel, Trelia
Soegiharto, Benny
Nazruddin
Ilyas, Syafruddin
Bachtiar, Hanna
Bachtiar, Adang
Auerkari, Elza Ibrahim
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2018 Hiroshima University Medical Press |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
PITX2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
vertical mandibular asymmetry |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
subdivision malocclusion |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Study on specific genetic pathways of condylar phenotype variation related to vertical mandibular asymmetry remain rare. PITX2, a gene active in the Nodal Pathway that determines the left-right symmetry during embryogenesis, has been reported in expression and regulation of skeletal-muscle development as well as differentiation of satellite cells in adult muscle. The aim of this study is to analyze the phenotypes of expressed PITX2 and its polymorphisms in vertical mandibular asymmetry based on skeletal and dental analysis. Pre-treatment panoramic radiographs from selected 62 orthodontics patients (20.7 ± 3.2 year old) were analyzed using Kjellberg symmetry Index. Subdivision of malocclusions that are limited to Angle’s classification was recorded. DNA material was obtained using buccal swabs, followed by Polymerase Chain Reaction (PCR) and Sanger sequencing with ChromasPro 2.13 software (Technelysium, Queensland, Australia) and then compared to archival data from gene bank number ENSG00000164093 (www.ensembl.org).Genotype analysis showed 3 polymorphisms (rs72554076, rs761511445, rs372257787) in 4'-UTR of 16 subjects (25.8%) with various vertical mandibular asymmetry causing a C>A change at 47-105 in 13 patients, G>A change at 47-9 in 1 patient and G>T change at 46+100 in 2 patients, respectively. The characteristics of vertical mandibular asymmetry and canine subdivision dominated in these subjects. Our findings suggest that complex polygenic trait of vertical mandibular asym metry should consider PITX2 polymorphisms that related to muscular disorder. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was partially supported by the TALENTA grants from the Universitas Sumatera Utara (5338/UN5.1.R/PPM/ 2017). |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
120 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 67,
p. 120-126,
発行日 2018-05
|
| 旧ID |
45854 |
HiroshimaJMedSci_67s_120.pdf (281.4 KB)
