| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
TNF - α Gene Polymorphism is Likely to be a Risk Factor for NASH in Indonesia |
|
言語 |
en |
| 作成者 |
Purnomo, Hery Djagat
Ep Mundhofir, Farmaditya
Kasno
Sudijanto, Edi
Darmono
Daldiyono
Mh Faradz, Sultana
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2018 Hiroshima University Medical Press |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Polymorphism TNF- α |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
risk factor |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
NASH |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Introduction : Non alcoholic steatohepatitis (NASH) is a subset spectrum of NAFLD that can progress toward cirrhosis. Tumor necrosis factor- α (TNF- α) polymorphism play a significant role in liver inflammation and Insulin resistance its pathophysiological hallmark. The association between TNF- α (-238 and -308) polymorphism) and the severity of NAFLD was evaluated. Method: A total of 155 subjects (80 NAFLD cases and 75 controls) were included. Liver biopsy was performed for evaluated severity of NAFLD based on NAFLD Activity Score-CRN in all cases. Controls subjects defined was not any liver disease by ultrasound. Plasma TNF– α was measured in all subjects. Polymorphism of` TNF- α promoter gene -308 and -238 were identified using PCR-RFLP confirmed with direct sequencing. Results: Liver biopsy established the diagnosis of NASH in 29 cases. There was no association between the incidence of NAFLD with TNF- α polymorphism at the TNF– α -308 or the -238 (p>0.05). The prevalence ratio of TNF– α polymorphism -238 was significantly higher for subject with NASH (p< 0.02). There was no different prevalence ratio for TNF– α polymorphism -308 (p>0,05). We found novel polymorphism of TNF- α -245 T/C in a subject with possible NASH, high plasma TNF- α level (20.27 pg/cc) and very high value of Homeostasis Model of Assessment - Insulin Resistance HOMA-IR (22.73). Conclusion : Polymorphism TNF- α -238 is likely to be a risk factor for NASH in Indonesia. The identification of new possible polymorphism of TNF- α -245 requires further study in more samples. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
101 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 67,
p. 101-109,
発行日 2018-05
|
| 旧ID |
45851 |
HiroshimaJMedSci_67s_101.pdf (583.1 KB)
