| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Positive Correlation between Ferritin and Activated Monocyte in Iron Overloaded Major β-thalassemia Patients |
|
言語 |
en |
| 作成者 |
Ghozali, M.
Anggia, M. Fariz
Tjahjadi, Adi Imam
Reniarti, Lelani
Ghrahani, Reni
Syamsunarno, MRAA.
Setiabudiawan, Budi
Panigoro, Ramdan
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2018 Hiroshima University Medical Press |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Monocyte |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
CD14 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
CD69 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
iron |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
β-thalassemia |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Introduction: Regular blood transfusion for β-thalassemia patients is a life-saving therapy, hence, it results in iron overload lead to immune dysregulation triggered by chronic activation of immune system. This fundamental notion contributes to their morbidity and mortality. Monocyte plays a critical role in regulating and bridging innate to adaptive immunity. Our pilot study analyzed the presence of activation markers, CD14 and CD69, on monocyte of major β-thalassemia patients associated with their iron status. Method: Fifty pediatric β-thalassemia patients routinely visited thalassemia clinic for clinical examination and blood transfusion were involved in this cross-sectional study. Flow cytometry applying antibody of CD14, HLA-DR, CD69 was used to dissect CD14+CD69+ monocytes from lysed-erythrocyte heparinized whole blood and defined as cell percentage also median fluorescent intensity (MFI) of CD69 of CD14+CD69+ monocytes. Iron status was indicated by ferritin and serum iron level. A correlation study was done. Results : We found 87.4% (76.1 – 91.4) CD14+CD69+ of dissected monocytes from iron overloaded pediatric β-thalassemia patients (Ferritin level: 3118 μg/L, 1675 – 9718). Positive correlation was found between percentage of CD14+CD69+ monocytes and ferritin level (r = 0.3, P = 0.04). Conclusion: Considering the function of CD14 and CD69 on monocyte and the iron accumulation, our result may implicate that pediatric major β-thalassemia patients have a tendency towards chronic inflammation. Future direction for research of our study aimed at discovering collateral activation of immune cells via monocyte to explain organ damage caused by iron overload is imperative. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This study was funded by national competitive research grants, RISBINIPTEKDOK 2016, ("Riset Pembinaan IPTEK Kedokteran 2016") from Ministry of Health, Republic of Indonesia. |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
78 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 67,
p. 78-83,
発行日 2018-05
|
| 旧ID |
45847 |
HiroshimaJMedSci_67s_78.pdf (351.3 KB)
