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  1. 広島大学の刊行物
  2. Hiroshima Journal of Medical Sciences
  3. 67巻

Muntingia calabura Leaves Extract, a Potential Gastroprotective Agent against Gastric Mucosal Damage Induced by Soft Drink and Alcoholic Beverages

https://hiroshima.repo.nii.ac.jp/records/2013764
https://hiroshima.repo.nii.ac.jp/records/2013764
60c74d8d-f844-4983-9630-ba044ae01a63
名前 / ファイル ライセンス アクション
HiroshimaJMedSci_67s_49.pdf HiroshimaJMedSci_67s_49.pdf (1.5 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Muntingia calabura Leaves Extract, a Potential Gastroprotective Agent against Gastric Mucosal Damage Induced by Soft Drink and Alcoholic Beverages
言語 en
作成者 Nadliroh, Ummi Chamidatun

× Nadliroh, Ummi Chamidatun

en Nadliroh, Ummi Chamidatun

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Banurusman, Dimas

× Banurusman, Dimas

en Banurusman, Dimas

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Istiadi, Hermawan

× Istiadi, Hermawan

en Istiadi, Hermawan

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Utomo, Astika Widy

× Utomo, Astika Widy

en Utomo, Astika Widy

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2018 Hiroshima University Medical Press
主題
主題Scheme Other
主題 alcohol
主題
主題Scheme Other
主題 soft drinks
主題
主題Scheme Other
主題 gastric mucosa
主題
主題Scheme Other
主題 Muntingia calabura
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Introduction. Exposures of alcoholic beverages and soft drinks have been notorious for their deleterious effect on gastric mucosal cell, causing disturbances on gastric mucosa. The high content of antioxidant in Muntingia calabura leaves have potentials to counteract the degeneration of gastric mucosal cells due to exposure of both drinks. This study aimed to evaluate the effects of flavonoids in Muntingia calabura ethanolic leaves extract (MCELE) as gastroprotective agents against the alcoholic beverages and soft drinks induced gastric mucosal damage. Method. Twenty four male wistar rats were divided into four groups respectively treated with 1,8 ml/200grBW 40%-alcoholic beverages (K1), 50 ml/day soft drink (K2), pre-treated with 500 mg/kg MCELE one hour before oral administration of 40%- alcoholic drinks (P1) and soft drink (P2). All rats were treated for 30 days. On the 31st day, the rats were teminated and the histological degrees of gastric mucosal damage were determined by modified scale of epithelial mucosa integrity Barthel-Manja. Results. The K1 and K2 group exhibited severe gastric mucosal injury, with observed ulceration percentages of 33,3% and 23,3% respectively. Meanwhile, the pre-treated MCELE groups (P1 and P2) exhibited significant protection of gastric mucosa histologically (p<0.001), showing 0,0% of ulceration on both groups. Conclusion. Soft drinks have degenerating effect as strong as the alcoholic beverages. The treatment with MCELE prior to 40%-alcoholic beverages and soft drinks has significantly protected gastric mucosa as ascertained by significant reduction of gastric mucosal injury and increase in normal gastric mucosa.
言語 en
出版者
出版者 Hiroshima University Medical Press
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0018-2052
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA00664312
開始ページ
開始ページ 49
書誌情報 Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences

巻 67, p. 49-55, 発行日 2018-05
旧ID 45843
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