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  1. 広島大学の刊行物
  2. Hiroshima Journal of Medical Sciences
  3. 67巻1号

Incidentally Found Primary Cerebral Malignant Melanoma Associated with Ota Nevus—Wide Dissemination after an Initial Phase of Slow Growth

https://hiroshima.repo.nii.ac.jp/records/2013742
https://hiroshima.repo.nii.ac.jp/records/2013742
7ae98980-83b9-46f6-b845-74997f5b5e9f
名前 / ファイル ライセンス アクション
HiroshimaJMedSci_67_21.pdf HiroshimaJMedSci_67_21.pdf (9.9 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Incidentally Found Primary Cerebral Malignant Melanoma Associated with Ota Nevus—Wide Dissemination after an Initial Phase of Slow Growth
言語 en
作成者 Tanoue, Natsuko

× Tanoue, Natsuko

en Tanoue, Natsuko

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Ummah, Fauziah C

× Ummah, Fauziah C

en Ummah, Fauziah C

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Hanada, Tomoko

× Hanada, Tomoko

en Hanada, Tomoko

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Takajo, Tomoko

× Takajo, Tomoko

en Takajo, Tomoko

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Kamil, Muhammad

× Kamil, Muhammad

en Kamil, Muhammad

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Askoro, Rofat

× Askoro, Rofat

en Askoro, Rofat

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Arita, Kazunori

× Arita, Kazunori

en Arita, Kazunori

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2018 Hiroshima University Medical Press
主題
主題Scheme Other
主題 primary malignant melanoma
主題
主題Scheme Other
主題 central nervous system
主題
主題Scheme Other
主題 Ota nevus
主題
主題Scheme Other
主題 leptomeningeal dissemination
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Primary cerebral malignant melanoma accounts for 1% of all melanomas and for 0.7% of all primary tumours of the central nervous system (CNS). We report an incidentally found primary malignant melanoma in the right temporal lobe of a 76-year-old woman with an Ota nevus on her right eyelid and sclera. The lesion was initially characterised by slow growth, followed by tumoural bleeding and wide leptomeningeal dissemination. Magnetic resonance imaging (MRI) during brain checkup demonstrated an 8-mm mass in the right uncus with high intensity on T1-weighted images. The mass grew slowly over the next two years, but asymptomatic tumoural haemorrhage eventually developed. The patient underwent tumour removal via right frontotemporal craniotomy. Extensive subarachnoid dissemination from the right temporal tumour was found; the pathologic diagnosis was malignant melanoma. Despite adjuvant therapy comprising whole-brain radiation and nivolumab, the patient died of severe leptomeningeal dissemination at 4.5 months after the operation (33 months after the initial MRI study). Our literature review found 46 cases of primary CNS malignant melanoma, predominantly in middle-aged to elderly individuals. The most frequent symptom was headache, followed by visual disturbance, nausea/vomiting, and hemiparesis. Only one other case of primary cerebral malignant melanoma had been found incidentally; 11 previously reported patients manifested congenital nevi (Ota nevus, n = 5; other nevi, n = 6). Six patients suffered tumoural haemorrhage, 4 experienced leptomeningeal dissemination, and 5 developed extracranial metastases. The median survival time of the patients was 31 months.
言語 en
出版者
出版者 Hiroshima University Medical Press
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.24811/hjms.67.1_21
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.24811/hjms.67.1_21
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0018-2052
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2433-7668
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA00664312
開始ページ
開始ページ 21
書誌情報 Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences

巻 67, 号 1, p. 21-29, 発行日 2018-03
旧ID 45929
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