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  1. 広島大学の刊行物
  2. Hiroshima Journal of Medical Sciences
  3. 65巻2号

High Excess Risk of Heart Disease Mortality among Hiroshima Atomic Bomb Male Survivors Exposed Near the Hypocenter

https://hiroshima.repo.nii.ac.jp/records/2013713
https://hiroshima.repo.nii.ac.jp/records/2013713
7a808fdb-e009-40ce-b2bb-5518e1b4fd03
名前 / ファイル ライセンス アクション
HiroshimaJMedSci_65_45.pdf HiroshimaJMedSci_65_45.pdf (1.2 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル High Excess Risk of Heart Disease Mortality among Hiroshima Atomic Bomb Male Survivors Exposed Near the Hypocenter
言語 en
作成者 Hara, Noriyuki

× Hara, Noriyuki

en Hara, Noriyuki

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Satoh, Kenichi

× Satoh, Kenichi

en Satoh, Kenichi

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Otani, Keiko

× Otani, Keiko

en Otani, Keiko

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Kawakami, Hideshi

× Kawakami, Hideshi

en Kawakami, Hideshi

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Ohtaki, Megu

× Ohtaki, Megu

en Ohtaki, Megu

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2016 Hiroshima University Medical Press
主題
主題Scheme Other
主題 Atomic-bomb survivors
主題
主題Scheme Other
主題 Dose-response relationship
主題
主題Scheme Other
主題 Exposure distance
主題
主題Scheme Other
主題 Heart disease mortality
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Heart disease (HD) mortality is the second leading cause of death in Japan. The HD mortality risk among Atomic bomb survivors is slightly positive but shows a statistically significant dose-response relationship with initial radiation dose, as reported by the Radiation Effects Research Foundation. In that report, dosimetry was based on initial radiation only, with the effect of indirect radiation dose not taken into consideration. The atomic bomb radiation, however, consisted of both initial and residual radiation. We reevaluated the dose-response relationship for HD mortality using exposure distance (ground distance between the location where exposed and the hypocenter) as a surrogate indicator of radiation dose. At Hiroshima University, a cohort study has been conducted with Hiroshima Atomic Bomb Survivors (ABS) since 1970. We selected 29605 subjects from the ABS who were exposed at 3.5 km or less from the hypocenter and alive on January 1, 1970. These subjects, referred to as “Hiroshima hibakusha" in this paper, were followed until December 31, 2010. We stratified the cohort data with respect to sex and age at the time of bombing (ATB) into 10-year age groups. For each stratum, by applying an extended Cox regression model with time-dependent covariates, we analyzed the risk of HD mortality using either initial radiation dose or exposure distance as an explanatory variable. The results indicate a high excess risk in males and older age ATB females who were exposed near the hypocenter. This difference may be explained by the effect of female sex hormone on the circulatory system among young age ATB females. Some unknown risk factor related to exposure distance was also implicated in the elevated risk of HD among the Hiroshima hibakusha, especially in males. This necessitates further study.
言語 en
内容記述
内容記述タイプ Other
内容記述 This research was supported in part by Grants-in-Aid for Scientific Research (A) 24249039 (2012–2014), and the Joint Usage/Research Center (RIRBM), Hiroshima University.
出版者
出版者 Hiroshima University Medical Press
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0018-2052
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA00664312
開始ページ
開始ページ 45
書誌情報 Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences

巻 65, 号 2, p. 45-51, 発行日 2016-06
旧ID 40782
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