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  1. 広島大学の刊行物
  2. Hiroshima Journal of Medical Sciences
  3. 64巻4号

Diagnostic Performance of Positron Emission Tomography for the Presurgical Evaluation of Patients with Non-lesional Intractable Partial Epilepsy : Comparison among 18F-FDG, 11C-Flumazenil, and 11C-Flumazenil Binding Potential Imaging Using Statistical Imaging Analysis

https://hiroshima.repo.nii.ac.jp/records/2013704
https://hiroshima.repo.nii.ac.jp/records/2013704
621620a2-7dd6-403f-9c88-aeb608624908
名前 / ファイル ライセンス アクション
HiroshimaJMedSci_64_51.pdf HiroshimaJMedSci_64_51.pdf (226.3 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Diagnostic Performance of Positron Emission Tomography for the Presurgical Evaluation of Patients with Non-lesional Intractable Partial Epilepsy : Comparison among 18F-FDG, 11C-Flumazenil, and 11C-Flumazenil Binding Potential Imaging Using Statistical Imaging Analysis
言語 en
作成者 Komoto, Daisuke

× Komoto, Daisuke

en Komoto, Daisuke

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Iida, Koji

× Iida, Koji

en Iida, Koji

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Higaki, Toru

× Higaki, Toru

en Higaki, Toru

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Kaichi, Yoko

× Kaichi, Yoko

en Kaichi, Yoko

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Takauchi, Komei

× Takauchi, Komei

en Takauchi, Komei

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Arihiro, Koji

× Arihiro, Koji

en Arihiro, Koji

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Kakita, Akiyoshi

× Kakita, Akiyoshi

en Kakita, Akiyoshi

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Hirokawa, Yutaka

× Hirokawa, Yutaka

en Hirokawa, Yutaka

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Awai, Kazuo

× Awai, Kazuo

en Awai, Kazuo

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Hiroshima University Medical Press
主題
主題Scheme Other
主題 Positron emission tomography
主題
主題Scheme Other
主題 18F-FDG
主題
主題Scheme Other
主題 11C-FMZ
主題
主題Scheme Other
主題 Epilepsy
主題
主題Scheme NDC
主題 490
内容記述
内容記述 To compare the diagnostic performance of 18F-FDG PET, 11C-FMZ PET, and 11C-FMZ BP imaging for the evaluation of patients with intractable partial epilepsy whose MRI findings are normal by using statistical imaging analysis. Ten patients underwent comprehensive presurgical evaluation, including PET studies, to assess the epileptic foci. The extent of cortical resection was based on the results of intracranial video-electroencephalography (IVEEG) monitoring and brain mapping under stimulation. The images of 10 patients and 30 controls were spatially normalized to templates generated in-house by non-rigid registration and the standardized images of the patients and controls were statistically compared. Epileptic focus candidates were visualized on a color map of axial images of each template and the focus site was identified in candidates for lobar location. In patients with Engel I postoperative seizure outcomes we assessed the sensitivity and specificity of the imaging methods for lobar focus localization. We also compared the concordance scores of patients with Engel I and Engel II-IV postoperative seizures. The sensitivity and specificity for lobar focus localization on 18F-FDG PET scans was 90.0% and 84.8%, respectively; it was 30.0% and 81.4% for 11C-FMZ PET, 40.0% and 66.7% for 11C-FMZ BP images, and 100.0% and 51.4% for 18F-FDG PET/11C-FMZ PET/11C-FMZ BP images. In one patient the epileptic focus not detected on 18F-FDG PET scans was shown on 11C-FMZ BP images. In patients with Engel I post-treatment seizures the concordance scores were significantly higher for 18F-FDG PET than 11C-FMZ PET and 11C-FMZ BP images (p < 0.05). With respect to sensitivity and specificity, 18F-FDG PET was superior to 11C-FMZ PET and 11C-FMZ BP imaging. However, in some patients with normal MRI results, 11C-FMZ BP studies may complement 18F-FDG PET findings in efforts to identify the epileptogenic lobar regions.
言語 en
出版者
出版者 Hiroshima University Medical Press
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0018-2052
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA00664312
開始ページ
開始ページ 51
書誌情報 Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences

巻 64, 号 4, p. 51-57, 発行日 2015-12
旧ID 39062
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