| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
A Water-soluble Extract from Culture Medium of Ganoderma lucidum Mycelia Suppresses the Development of Colorectal Adenomas |
|
言語 |
en |
| 作成者 |
Oka, Shiro
Tanaka, Shinji
Yoshida, Shigeto
Hiyama, Toru
Ueno, Yoshitaka
Ito, Masanori
Kitadai, Yasuhiko
Yoshihara, Masaharu
Chayama, Kazuaki
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
(c) Hiroshima University Medical Press. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Ganoderma lucidum |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Colorectal adenoma |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cancer prevention |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Clinical trial |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
A water-soluble extract from a cultured medium of Ganoderma lucidum mycelia (MAK) is one of the G. lucidum extracts that has been reported to show have exhibit cancer-preventive effects in the animal studies. To confirm cancer-preventive effects of MAK, we performed a no-treatment concurrent controlled trial on patients with colorectal adenomas. Patients who were determined to be carrying colorectal adenomas by colonoscopy were enrolled in this study. Patients in the MAK group took MAK (1.5 g/day) for 12 months. Follow-up colonoscopy was performed after 12 months, and the colonoscopists recorded the size, site and macroscopic type of all adenomas. Among 123 patients who enrolled in the MAK group, 96 eligible patients completed the trial. The 102 eligible patients in the no-treatment control group were selected randomly from our department's patients. The changes in the number of adenomas up to 12 months increased to 0.66 ± 0.10 (mean± SE) in the control group, while decreasing in the MAK group to -0.42 ± 0.10 (p<0.01). The total size of adenomas increased to 1.73 ± 0.28 mm in the control group and decreased to -1.40 ± 0.64 mm in the MAK group (p<0.01). The results suggest that MAK suppresses the development of colorectal adenomas - precancerous lesions of the large bowel. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
1 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 59,
号 1,
p. 1-6,
発行日 2010-03
|
| 旧ID |
34972 |
HiroshimaJMedSci_59_1.pdf (1.3 MB)
