| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2006-03-21 |
| タイトル |
|
|
タイトル |
Damage of the Mouse Testis by Tritiated Water and <137>^Cs-γ-Rays |
|
言語 |
en |
| 作成者 |
Kashiwabara, Shoji
Kashimoto, Naoki
Sanoh, Seigo
Uesaka, Toshihiro
Katoh, Osamu
Watanabe, Hiromitsu
|
| 寄与者 |
|
|
|
姓名 |
国立情報学研究所 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Tritiated water |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cs-γ-rays |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Mouse |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Testis |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Tritiated water at 23.2, 46.3 or 92.5 MBq/animal and <137>^Cs-γ-rays at 9.5 Gy (equivalent 370 MBq) or lower doses were administered to 6-week old male C3H/HeNCrj and C57BL/6NCrj mice, as well as FI Crj: B6C3F1 (C3H × C57BL) progeny. Each set of six to ten animals were autopsied 30 days after the first irradiation. Testis weights were decreased dose dependently, relative values being highest in the C3H and lowest in the C57BL case, with B6C3F1 intermediate. Vacuolization in seminiferous tubules appeared in the 23.2 MBq group and increased with the dose. Focal pyknosis and karyomegaly were found at 46.3 MBq, while primary and secondary spermatocytes and spermatids disappeared with 92.5 MBq. Only a few spermatogonia and Sertoli cells remained after exposure to 9.5 Gy <137>^Cs-γ-rays. Sizes of seminiferous tubules were decreased dose dependently, with no strain differences. When male B6C3F1 mice were irradiated with Cs-γ-rays at 0.119 (equivalent 4.63 MBq tritiated water) or 2.38 Gy (equivalent 92.5 MBq tritiated water), body weights and size of the seminiferous tubules were decreased at both doses, and the larger dose also caused reduction of testis weight and abnormal sperm. However, all changes except for the alteration in weights had disappeared 1 month after the final irradiation. It is considered that the size of seminiferous tubules may be a good parameter for radiation damage in the testis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 日付 |
|
|
日付 |
2006-03-21 |
|
日付タイプ |
Created |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
53 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 52,
号 3,
p. 53-58,
発行日 2003-09
|
| 旧ID |
734 |
KJ00000705989.pdf (1.2 MB)
