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  1. 広島大学の刊行物
  2. Hiroshima Journal of Medical Sciences
  3. 52巻3号

Trans-vertebral Regional Cooling for Spinal Cord Protection during Thoracoabdominal Aortic Surgery : An Experimental Study

https://hiroshima.repo.nii.ac.jp/records/2013535
https://hiroshima.repo.nii.ac.jp/records/2013535
22e5a1ac-c2ff-4a5a-8aaa-6be438022756
名前 / ファイル ライセンス アクション
KJ00000705987.pdf KJ00000705987.pdf (1.3 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2006-03-21
タイトル
タイトル Trans-vertebral Regional Cooling for Spinal Cord Protection during Thoracoabdominal Aortic Surgery : An Experimental Study
言語 en
作成者 Sugawara, Yuji

× Sugawara, Yuji

en Sugawara, Yuji

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Sueda, Taijiro

× Sueda, Taijiro

en Sueda, Taijiro

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Orihashi, Kazumasa

× Orihashi, Kazumasa

en Orihashi, Kazumasa

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Okada, Kenji

× Okada, Kenji

en Okada, Kenji

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Kochi, Kazuhiro

× Kochi, Kazuhiro

en Kochi, Kazuhiro

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Imai, Katsuhiko

× Imai, Katsuhiko

en Imai, Katsuhiko

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寄与者
姓名 国立情報学研究所
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
主題Scheme Other
主題 Spinal cord ischemia
主題
主題Scheme Other
主題 Spinal cord protection
主題
主題Scheme Other
主題 Cooling method
主題
主題Scheme Other
主題 Thoracoabdominal aortic surgery
主題
主題Scheme NDC
主題 490
内容記述
内容記述 We developed a simple cooling method for spinal cord protection against ischemic injury during aortic surgery. The neuroprotective effects of our method were investigated using an animal study. Selective spinal hypothermia was produced by means of originally-designed cooling pads placed over the lower thoracic and lumbar vertebral column. Spinal cord ischemia was induced by cross-clamping the thoracic aorta for 60 min in beagle dogs. The neuroprotective effects were evaluated by a multi-modal study. The motor-evoked potentials of the spinal cord resulting from transcranial electric stimulation (MEPs) were recorded during both the ischemic and reperfusion periods. Hindlimb motor function was graded with the Tarlov score, and a histologic examination of the spinal cord injury was performed, at 24 hours after ischemia in animals undergoing hypothermia (hypothermia group: n = 7) or a sham (control group: n = 7). The spinal cord temperatures at the lower thoracic (T10) and lumbar (L3) levels decreased by -9.1°C per hour and -8.1°C per hour, respectively. The amplitude of the MEPs decreased during ischemia in both groups of animals, and significantly recovered during the early phase of aortic reperfusion in the hypothermia group. The Tarlov scores in the hypothermia and control groups were 3.3 ± 1.0 and 1.1 ± 1.5 (mean ± SD, p = 0.015), respectively. Histopathologic study revealed that ischemic injury of the lumbar cord was reduced in the animals undergoing hypothermia. Trans-vertebral regional cooling reduced ischemic spinal cord injury in a canine study. The current method is potentially feasible for clinical use, especially in view of its technical simplicity and few procedure-related complications.
言語 en
出版者
出版者 Hiroshima University Medical Press
日付
日付 2006-03-21
日付タイプ Created
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0018-2052
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA00664312
開始ページ
開始ページ 35
書誌情報 Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences

巻 52, 号 3, p. 35-41, 発行日 2003-09
旧ID 732
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