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Alterations in Palatal Ruga Patterns in Jcl:ICR Mouse Fetuses from Dams Treated with All-trans-retinoic Acid
https://hiroshima.repo.nii.ac.jp/records/2013500
https://hiroshima.repo.nii.ac.jp/records/201350014337f30-c444-494d-9d32-7e24bafb6275
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_50_17.pdf (1.2 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Alterations in Palatal Ruga Patterns in Jcl:ICR Mouse Fetuses from Dams Treated with All-trans-retinoic Acid | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Horie, Shigeaki
× Horie, Shigeaki
× Yasuda, Mineo
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Retinoic acid | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Palatal ruga | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Mouse | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Cleft palate | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | Pregnant Jcl:ICR mice were orally given all-trans-retinoic acid (RA) at dose levels from 0.08 to. 80 mg/kg once at days 10.5, 11.5, or 12.5 (vaginal plug = day 0) of gestation. The dams were sacrificed at day 18.5 of gestation, and the fetuses were dissected. After fixation in Bouin's solution, the fetal palates were observed under a dissecting microscope. Pattern alterations rare in the control fetuses were shortness, fusion, maldirection, trirugal malalignment, modified cross, and cross. These alterations were defined as abnormalities. Cleft palate was induced at dose levels of 20 mg/kg and above. At each treatment day, the total incidence of abnormal rugae increased from the dose of 0.3 or 0.6 mg/kg, dose-dependently. Although missing ruga-8 was a common pattern alteration in vehicle controls, its incidence increased dose-dependently. The incidence of supernumerary posterior to ruga 3 increased dose-dependently after treatment at day 11.5 or day 12.5 of gestation, however the increase was not observed after treatment at day 10.5 of gestation. These findings indicate that the abnormalities of ruga, missing ruga-8 and supernumerary posterior to ruga 3 are very sensitive indicators of teratogenicity of RA. | |||||||||
| 言語 | en | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | This work was supported by a grant from the Ministry of Health and Welfare of Japan. | |||||||||
| 出版者 | ||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0018-2052 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00664312 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 17 | |||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 50, 号 1, p. 17-25, 発行日 2001-03 |
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| 旧ID | 37681 | |||||||||
