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  1. 広島大学の刊行物
  2. Hiroshima Journal of Medical Sciences
  3. 49巻4号

Is Communication to Endocardium Necessary for Angiogenesis in Transmyocardial Laser Revascularization?

https://hiroshima.repo.nii.ac.jp/records/2013495
https://hiroshima.repo.nii.ac.jp/records/2013495
db4836c1-215c-4392-9474-2f01acc0fd1c
名前 / ファイル ライセンス アクション
HiroshimaJMedSci_49_157.pdf HiroshimaJMedSci_49_157.pdf (1.2 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Is Communication to Endocardium Necessary for Angiogenesis in Transmyocardial Laser Revascularization?
言語 en
作成者 Shibamura, Hidenori

× Shibamura, Hidenori

en Shibamura, Hidenori

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Imanishi, Kaoru

× Imanishi, Kaoru

en Imanishi, Kaoru

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Kajihara, Hiroki

× Kajihara, Hiroki

en Kajihara, Hiroki

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Matsuura, Yuichiro

× Matsuura, Yuichiro

en Matsuura, Yuichiro

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Sueda, Taijiro

× Sueda, Taijiro

en Sueda, Taijiro

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Orihashi, Kazumasa

× Orihashi, Kazumasa

en Orihashi, Kazumasa

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
主題
主題Scheme Other
主題 Transmyocardial laser revascularization
主題
主題Scheme Other
主題 Angiogenesis
主題
主題Scheme Other
主題 Blood flow through the laser channels
主題
主題Scheme NDC
主題 490
内容記述
内容記述 There is evidence of angiogenesis being induced after transmyocardial laser revascularization (TMLR), although the precise mechanism has not been fully elucidated. This study was designed to examine whether or not blood flow from the left ventricle through the channels is essential for angiogenesis following TMLR.   Ten dogs underwent the creation of two types of laser channels in the left ventricle: 1) a transmural channel (TMC), which penetrates the myocardium, and 2) a non-transmural channel (NTMC), which does not open to the epicardium. The animals were sacrificed on the 28th postoperative day and the vascular density was examined. Vessels with smooth muscle media were seen within or around the channel remnant. The vessel density was compared between TMC and NTMC. The outer and inner halves of the myocardium in the TMC region were compared in the same way.   The density of vessels within and around the channel remnants was significantly higher in TMC than in NTMC (1.439 versus 0.685 vessels/microscopic visual field (mvf=40X); p=0.0025). The vascular density was significantly higher in the region adjacent to TMC than in a distant region (>3 mm from the channel center). The vascular density was significantly higher in the outer half than in the inner half of the myocardium (1.730 versus 1.180 vessels/mvf: p=0.0459).   These findings demonstrate that communication to the left ventricular lumen enhances angiogenesis of TMLR, although blood flow in the channel did not exist 4 weeks after TMLR and angiogenesis tended to be more highly enhanced in the outer half than in the inner half of the myocardium.
言語 en
出版者
出版者 Hiroshima University Medical Press
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ departmental bulletin paper
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 0018-2052
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA00664312
開始ページ
開始ページ 157
書誌情報 Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences

巻 49, 号 4, p. 157-165, 発行日 2000-12
旧ID 37719
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