| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Protective Effects of Pretreatment with Ginsenosides on Cardiac and Coronary Vascular Function After Hypothermic Rat Heart Preservation |
|
言語 |
en |
| 作成者 |
Zhang, Jie-Min
Matsuura, Yuichiro
Sueda, Taijiro
Orihashi, Kazumasa
Fukunaga, Shintaro
Watari, Masanobu
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Langendorff perfusion |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Heart preservation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Ginsenosides |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Reperfusion damage |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Prevention of cardiac and vascular dysfunction with pretreatment has been accepted as an important factor in heart transplantation. Ginsenosides (GS) have been reported to have some beneficial effects on the cardiac and vascular system. We hypothesized that pretreatment with GS would result in an improvement of functional recovery after a 12 hour (hr) rat heart preservation. A Langendorff apparatus was applied to estimate the cardiac and vascular function in an isolated rat heart preparation. The hearts were preserved in University of Wisconsin solution at 0°C for 12hr, after pretreatment with 0.9% sodium chloride or GS 100 mg/kg, respectively, in control (n = 9) and GS (n = 14) groups. After storage, the cardiac function, myocardial water content, and coronary vasodilatory response were evaluated. The GS group showed a significantly higher recovery percentage of cardiac function compared with the control group: aortic flow 81.4 ± 21.4% versus 57.2 ± 11.0% (p = 0.0052); coronary flow 81.4 ± 14.5% versus 57.2 ± 6.0% (p = 0.0001); ±dp/dt max 72.5 ± 16.1 % and 66.0 ± 16.1 % versus 53.7 ± 4.1 % and 51.4 ± 7.1 % (p = 0.0027 and p = 0.0189) respectively. The GS group showed a lower increase in myocardial water content. With Langendorff perfusion, the endothelial and vascular smooth-muscle cell function were evaluated by an increasing percentage of coronary flow in response to acetylcholine chloride (0.3 × 10-7 mol/liter) and nitroglycerin (0.5 × 10-5 mol/liter). It was significantly higher in the GS group than that in the control group (19.2 ± 8.8% and 28.0 ± 14.1% versus 9.9 ± 4.7% and 14.7 ± 8.1%, p = 0.008 and p = 0.0187, respectively) at the first minute. These results suggest a protective effect on ventricular and coronary vascular function in the rats pretreated with Ginsenosides, indicating potential benefits for long-term heart preservation. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
65 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 48,
号 2,
p. 65-70,
発行日 1999-06
|
| 旧ID |
37732 |
HiroshimaJMedSci_48_65.pdf (651.2 KB)
