| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Beneficial Effects of Perfluorotributylamine/Pluronic F-68 Stem-Emulsion (FC43se) on Discordant Lung Xenografts |
|
言語 |
en |
| 作成者 |
Okada, Kenji
Wada, Seishi
Kajihara, Hiroki
Sueda, Taijiro
Matsuura, Yuichiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Perfluorochemical |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Discordant xenograft |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Lung transplantation |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The aim of this study was to assess the effectiveness of Perfluorotributylamine/Pluronic F-68 Stem-Emulsion (FC43se) against hyperacute rejection in rabbit-pig xenodiscordant transplantation in an ex-vivo lung model. Rabbits were divided into two groups. In Group 1 (control), after extraction, the lungs were connected directly to the experimental circuit as soon as possible. The lungs were then perfused with 100 ml of pig blood only. In Group 2 (FC(+) Group), after extraction, the lungs were connected to the same circuit as soon as possible. The lungs were then perfused with 10 ml of FC43se plus 90 ml of pig blood. The duration of perfusion was defined from when the perfusion started until the PAP reached 50 mmHg. Significant differences in survival were seen between Group 1 and Group 2: in Group 1, the survival time was 51.9±16.8 min, whereas in Group 2 the survival time was 76.9±12.4 min (p<0.01). The wet-to-dry weight ratio after 30 min of perfusion in Group 2 was significantly lower than that of Group 1 and the mean pulmonary artery pressure of Group 2 at 35, 40 and 45 min after perfusion was significantly lower than that of Group 1. Histological examination revealed that FC43se suppressed the adhesion of leukocytes to the surfaces of endothelial cells, and also attenuated the intimal edematous changes accompanying leukocyte infiltration. Therefore, FC43se has a beneficial effect on suppressing hyperacute rejection in xenogeneic discordant lung transplantation. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
115 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 46,
号 4,
p. 115-123,
発行日 1997-12
|
| 旧ID |
37827 |
HiroshimaJMedSci_46_115.pdf (944.9 KB)
