| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Effects of Acute Arterial Bleeding on Renal Sympathetic Nerve Activity in Young and Old Anesthetized Rats |
|
言語 |
en |
| 作成者 |
Kohata, Shuji
Ninomiya, Isio
Shinizu, Junichi
Furukawa, Kazuto
Matsuura, Yuichiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Renal nerve activity |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Acute arterial bleeding |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Aging |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
We compared the change in renal sympathetic nerve activity (RNA) during hemorrhage in young and old rats. Young (10 weeks) and old (80 weeks) male Wistar rats were anesthetized, and RNA together with arterial pressure (AP) and heart rate (HR) were measured under spontaneous respiration. Acute arterial bleeding, lm1Jl00g body weight, was carried out to induce hypotension and hypovolemia. With bleeding, mean AP (MAP) decreased from 110 ± 12 to 23 ± 11mmHg (mean ± SEM) and from 93 ± 15 to 15 ± 6mmHg in young and old rats, respectively. The difference in the change of MAP between the young and old rats was not significant. With bleeding, mean RNA increased by 46 ± 21 % and 20 ± 16% in young and old rats, respectively. The increase in mean RNA of the old rats was significantly lower than that of the young rats. We estimated the gain of the barocepter-renal sympathetic nervous system by using the formula ∆RNA/RNA/∆MAP/MAP. The gain was 0.61 ± 0.34 and 0.23 ± 0.18 in young and old rats, respectively. The difference in the gain was statistically significant (p<0.05). We concluded that the gain of baroceptor-sympathetic nerve system in acute arterial hemorrhage is attenuated with aging. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
87 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 46,
号 3,
p. 87-92,
発行日 1997-09
|
| 旧ID |
37822 |
HiroshimaJMedSci_46_87.pdf (712.8 KB)
