| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Protective Effect of Beraprost Sodium, a Stable Prostacyclin Analogue, on Cardiac Allograft Vasculopathy in Rats |
|
言語 |
en |
| 作成者 |
Kurisu, Yoshihiro
Orihashi, Kazumasa
Sueda, Taijiro
Kajihara, Hiroki
Matsuura, Yuichiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Cardiac allograft vasculopathy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Heart transplantation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Beraprost |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Prostagrandin I2 |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Intimal thickening and luminal narrowing of the coronary arteries are insidious complications of cardiac allograft. However, the pathogenesis of cardiac allograft vasculopathy (CAV) remains to be clarified. In this study, the protective effect of a prostacyclin analogue (beraprost sodium; BPS) on CAV was evaluated after heterotopic cardiac transplantation in rat. All recipients were treated with cyclosporine A (10 mg/kg/day intramuscularly). Eight rats received oral therapy with BPS of 50 μg/kg/day (BPS group) and another 8 rats received vehicle only (control group). All surviving cardiac grafts were removed on the 60th postoperative day and were examined to determine the severities of cellular rejection and CAV (>50 μm in diameter). Additionally, 6-keto-prostagrandin Fla and thromboxane B2 were compared between the two groups. There was no significant difference in the grading score for cellular rejection based on the ISHLT grading system (2.31 ± 0.75 vs 2.47 ± 0.65, p=0.81). Although the endothelial cells were preserved in both groups, a deposition of fibrin-like dense materials was recognized in the subendothelial layers of the control group, but not in the BPS group. Intimal thickening was inhibited significantly in the BPS group. The intimal ratio (intimal area/sectional area of artery) was significantly lower in the BPS group than in the control group (0.134 ± 0.03 vs 0.205 ± 0.047; p<0.01), without any difference in the medial ratio (medial area/sectional area of artery). a-actin positive smooth muscle cells (SMC) in intima were fewer in number in the BPS group than in the control group. The plasma thromboxane B2 level was significantly lower in the BPS group than in the control group (270 ± 116 pg/ml vs 585 ± 258 pg/mg; p<0.01). It was concluded that BPS suppressed CAV development after heterotopic allogenic cardiac transplantation in rats. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This study was presented at the 31th annual meeting of the Japan Society for Transplantation in September 1995, at the 36th annual meeting of the Japanese College of Angiology, November 1995, and at the 96th annual congress of the Japan Surgical Society in April 1996. |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
11 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 46,
号 1,
p. 11-19,
発行日 1997-03
|
| 旧ID |
37813 |
HiroshimaJMedSci_46_11.pdf (1.4 MB)
