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Enhancement of Host Resistance to Microbial Infections in Mice Fed a High Fat Diet by Lactobacillus casei Cells
https://hiroshima.repo.nii.ac.jp/records/2013392
https://hiroshima.repo.nii.ac.jp/records/2013392b7922f2f-853b-40bf-8804-89a420a9d58d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_45_63.pdf (610.7 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Enhancement of Host Resistance to Microbial Infections in Mice Fed a High Fat Diet by Lactobacillus casei Cells | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Watanabe, Takashi
× Watanabe, Takashi
× Hotta, Chizuko
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Lactobacillus casei | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | High fat diet | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Opportunistic infection | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Immunosuppressed mouse | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | The carbon clearance ability of female ddY mice was markedly reduced by feeding with a high fat-low carbohydrate (HFLC) diet for 8 weeks. The reduced clearance ability was restored by a single intraperiotoneal (ip) injection with heat-killed Lactobacillus casei (YIT 9018) cells (LC 9018). The ip injection of LC 9018 into the HFLC diet-fed mice led to a remarkable enhancement of nonspecific resistance when they were exposed to 50% lethal doses of Pseudomonas aeruginosa or herpes simplex virus, type 1. The resistance-enhancing capacity of LC 9018 against P. aeruginosa infection was significantly maintained for 7 days after the ip inoculation with LC 9018 in mice fed the HFLC diet. The reduced in vivo killing activity of peritoneal exudate cells (macrophage-rich) from mice fed the HFLC diet to P. aeruginosa infection was markedly augmented by the ip administration of LC 9018. The results indicate that LC 9018, one of the bacterial immunostimulants, may restore the reduced host defense functions in mice induced by feeding with a high fat diet for a long period. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0018-2052 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00664312 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 63 | |||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 45, 号 2, p. 63-68, 発行日 1996-06 |
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| 旧ID | 37842 | |||||||||
