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Biochemical Studies of Inherited Diseases Related to Abnormal Cholesterol Metabolism. II : Absence of Unusual C2s and C29 Bile Acid Homologs in Bile and Urine of Sitosterolemia
https://hiroshima.repo.nii.ac.jp/records/2013345
https://hiroshima.repo.nii.ac.jp/records/2013345c8bfd077-77b2-46cb-900a-35e938441eb4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_43_81.pdf (550.7 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Biochemical Studies of Inherited Diseases Related to Abnormal Cholesterol Metabolism. II : Absence of Unusual C2s and C29 Bile Acid Homologs in Bile and Urine of Sitosterolemia | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Ohshima, Akira
× Ohshima, Akira
× Une, Mizuho
× Hoshita, Takahiko
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| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Sitosterolemia | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Sitosterol | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Campesterol | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Bile acid | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Bile alcohol | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Bile acids, bile alcohols and sterols excreted in bile and urine from a patient with sitosterolemia were studied. Glycine- and taurine-conjugated cholic acid, deoxycholic acid and chenodeoxycholic acid were identified as the major constituents of both the bile and urine. Lesser amounts of unconjugated cholic acid and 3a, 7a, 12a, 24-tetrahydroxy-5B-cholestan-26-oic acid were found in the bile, but cholic acid was the only unconjugated bile acid in the urine. Relatively high proportions of campesterol and sitosterol compared to cholesterol were excreted in the bile, while cholesterol was the only sterol detected in the urine. Bile alcohols were not detected in the bile, but the following bile alcohols were excreted in the urine as glucurono-conjugates: 5β-cholestane-3α, 7α,12α,25-tetrol; 27-nor-5β-cholestane-3α, 7α,12α,24,25-pentol; 5β-cholestane-3α, 7α,12α,23 ,25-pentol; 5β-cholestane-3α, 7α,12α,24,25-pentol; 5β-cholestane-3α, 7α,12α,25,26-pentol. In neither the bile nor urine, were C28 and C29 bile acid homologs detected. Thus, the main route for the excretion of plant sterols in sitosterolemia is thought to be secretion into the bile as neutral sterols. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00664312 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 81 | |||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 43, 号 3, p. 81-86, 発行日 1994-09 |
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| 旧ID | 37884 | |||||||||||
