| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Cytogenetic Abnormalities of Hematopoietic Tissue in Retired Workers of the Ohkunojima Poison Gas Factory |
|
言語 |
en |
| 作成者 |
Shakil, Fouzia A.
Kuramoto, Atsushi
Yamakido, Michio
Nishimoto, Yukio
Kamada, Nanao
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Mustard gas |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Chromosome abnormality |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Sister chromatid exchange |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Chronic myelocytic leukemia |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
A high incidence of cancer of the respiratory tract has been reported among former workers in a poison gas manufacturing plant which operated on Ohkunojima from 1927 to 1945. This report provides evidence of a high incidence of chromosome abnormality and sister chromatid exchange (SCE) rate among the former workers, as well as cytogenetic changes in two patients among the former workers with chronic myelocytic leukemia (CML). A chromosome study of seven former workers with chronic bronchitis revealed a stable type of aberration, the average abnormality being 10.9 ± 4.4 percent, which is equivalent to those of atomic bomb survivors exposed at 1.2 km from the hypocenter. The SCE rate observed in 16 former workers ranged from 4.9 ± 2.1 to 17.8 ± 3.9, which was significantly higher than in the control group (p<0.03). One of the CML patients showed an extremely high percentage of missing Y chromosomes along with t(9;22) translocation which is a specific chromosome aberration for the disease. Furthermore, the patient had almost a 3 times higher SCE rate compared to the control group and a high incidence of chromosome abnormality (12.1 %) of the peripheral lymphocytes. These results suggest that the development of leukemia in this patient was strongly related to poison gas exposure. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported in part by grants-in-aid from the Ministry of Education, Science and Culture and from the Japan Public Health Association's A-Bomb Survivors Joint Research Team supported by FY 1992 Health and Welfare Ministry A-Bomb Disease Investigation and Research Entrustment Fund (Shigematsu Collaborative Study Group). |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
159 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 42,
号 4,
p. 159-165,
発行日 1993-12
|
| 旧ID |
37932 |
HiroshimaJMedSci_42_159.pdf (921.5 KB)
