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Secretion of Somatostatin and Gastrin by Human Antral Mucosa : An in vitro study in duodenal ulcer patients and control subjects under stimulation of bombesin
https://hiroshima.repo.nii.ac.jp/records/2013316
https://hiroshima.repo.nii.ac.jp/records/20133167bf57827-4044-4b9f-a8a1-813a5883d7e3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_42_33.pdf (1.1 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Secretion of Somatostatin and Gastrin by Human Antral Mucosa : An in vitro study in duodenal ulcer patients and control subjects under stimulation of bombesin | |||||||
| 言語 | en | |||||||
| 作成者 |
Hou, Wei
× Hou, Wei
|
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Somatostatin and gastrin secretion | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Bombesin | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Organ culture | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Duodenal ulcer | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | In order to ascertain possible abnormalities in somatostatin and gastrin secretion in patients with duodenal ulcer, the author compared bombesin-stimulated somatostatin and gastrin secretion by antral mucosal explants in patients with duodenal ulcer, those with atrophic gastritis and normal controls. An organ culture technique was employed. This excluded neurogenic, hormonal and circulatory influences. Bombesin in concentrations of 10-7 M to 10-5 M stimulated gastrin and somatostatin secretion at a dose-dependent manner. In all subjects, bombesin (10-7M) stimulated antral gastrin release and increased explant gastrin content significantly (p<0.05). Bombesin significantly increased somatostatin release and explant somatostatin content in normal subjects (p<0.05) but not in patients with duodenal ulcer (p>0.05). In the presence of bombesin, the total net increase of gastrin in medium and explants was greater in duodenal ulcer patients (31.57 ± 5.20 ng/mg wet w.) compared with normal subjects (19.63 ± 4.50 ng/mg wet w.) (p<0.01). The total net increase of somatostatin in the presence of bombesin was significantly less in duodenal ulcer patients (0.10 ± 0.02 ng/mg wet w.) than in normal subjects (1.45 ± 0.24 ng/mg wet w.) (p<0.01). The results suggest that abnormalities in somatostatin and gastrin secretion of the antrum contribute to the pathogenesis of increased gastric acid secretion in duodenal ulcer. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University Medical Press | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 8098023 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 33 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 42, 号 1, p. 33-40, 発行日 1993-03 |
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| 旧ID | 37913 | |||||||
