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Effects of in vivo Pretreatment with Various Barbiturates on Anaerobic Halothane Metabolism in Rat Liver Microsomes
https://hiroshima.repo.nii.ac.jp/records/2013268
https://hiroshima.repo.nii.ac.jp/records/2013268446bdb14-7b29-44eb-978a-9eb6111c05e7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_39_125.pdf (478.3 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Effects of in vivo Pretreatment with Various Barbiturates on Anaerobic Halothane Metabolism in Rat Liver Microsomes | |||||||||||||||
| 言語 | en | |||||||||||||||
| 作成者 |
Taira, Yutaka
× Taira, Yutaka
× Fujii, Kohyu
× Kikuchi, Hirosato
× Yuge, Osafumi
× Morio, Michio
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| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Anesthetics; halothane, barbiturates. | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Biotransformation; dehalogenation, induction. | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | Microsomes; rat, liver. | |||||||||||||||
| 主題 | ||||||||||||||||
| 主題Scheme | NDC | |||||||||||||||
| 主題 | 490 | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述 | The effects of in vivo pretreatment with phenobarbital (PB), thiopental (TP), thiamylal (TA), pentobarbital (PT), and secobarbital (SB) on hepatic microsomal enzymes, and the effects on anaerobic halothane dehalogenation, aminopyrine N-demethylation, and aniline hydroxylation in the microsomes were studied in male Wistar rats. Three hundred twenty μmol/kg (0.1ml) of PB, TP, TA, PT, SB, or 0.1ml of 0.9% saline were administered daily, intramuscularly, for periods of one day up to ten days. Daily administration of PB, TP, TA, or PT induced cytochrome P-450, NADPH-cytochrome P-450 reductase and/or cytochrome b5. However, administration of SB did not induce these enzymes. The potency of these enzyme inductions ranged in descending order as follows: PB, TP, TA, and PT. After five days of daily administration of PB, TP, or TA, the production of the anaerobic halothane metabolite, CDFE, increased to 187%, 134%, and 130% of the control, respectively. The production of another halothane metabolite, CTFE, likewise increased to 197%, 168%, and 163%. However, pretreatment with PT or SB had no effect on anaerobic halothane dehalogenation. Aminopyrine N-demethylation also increased after five days of daily administration of PB, TP, and TA. However, aniline hydroxylation decreased after five days of daily administration of TA. Other barbiturates had no effect on aniline hydroxylation. In this study we showed that whereas PT and SB did not enhance anaerobic halothane dehalogenation, PB, TP and TA did. We conclude that not only PB, and also TP and TA, may be enhancing factors in halothane hepatotoxicity. We recommend that, if barbiturates are necessary, SB and PT be used in the preadministration of halothane anesthesia. | |||||||||||||||
| 言語 | en | |||||||||||||||
| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | This study was supported in part by a Research Grant from the Japanese Ministry of Education, Science and Culture. | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
| 関連情報 | ||||||||||||||||
| 識別子タイプ | PMID | |||||||||||||||
| 関連識別子 | 2086563 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||||||
| 収録物識別子 | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA00664312 | |||||||||||||||
| 開始ページ | ||||||||||||||||
| 開始ページ | 125 | |||||||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 39, 号 4, p. 125-130, 発行日 1990-12 |
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| 旧ID | 38089 | |||||||||||||||
