| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
A Comparative Study on Reductive Dehalogenation of Halothane in Liver, Kidney and Lung of the Rabbit |
|
言語 |
en |
| 作成者 |
Inoue, Tetsuhide
Fujii, Kohyu
Kikuchi, Hirosato
Yuge, Osafumi
Morio, Michio
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Halothane |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Reductive dehalogenation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Microsome |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Extrahepatic organs |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The contents of cytochrome P-450 (P-450) and cytochrome b5, and the activity of NADPH-cytochrome c reductase and the reductive metabolites of halothane, 2-chloro-1, 1-difluoroethylene (CDE) and 2-chloro-1, 1, 1-trifluoroethane (CTE) were measured in microsomes from the liver, kidney and lung of phenobarbital (PB) pretreated and untreated Japanese white strain rabbits. Microsomal P-450 levels in the liver, kidney (renal cortex) and lung of the rabbits were 1.91 ± 0.35, 0.19 ± 0.04 and 0.42 ± 0.11 nmol/mg protein (mean ± SD), respectively. In vivo phenobarbital pretreatment (PB-pretreatment) increased the content of P-450 to 2.95 ± 0.40 nmol/mg protein (154%) in the liver and to 0.40 ± 0.11 nmol/mg protein (211 %) in the kidney, but had little effect in the lung. The activity of CDE formation was 0.72 ± 0.10, 0.08 ± 0.04 and 0.03 ± 0.01 nmol/mg protein/ min in the liver, kidney and lung, respectively. PB-pretreatment enhanced the activity of CDE formation to 1.59 ± 0.49 nmol/mg protein (221 %) in the liver, and to 0.29 ± 0.16 nmol/mg protein/min (363%) in the kidney, but showed little enhancement in the lung. The activity of CTE formation was 1.30 ± 0.19, 0.12 ± 0.04 and 0.09 ± 0.02 nmol/mg protein/min, in the liver, kidney and lung, respectively. PB-pretreatment enhanced the activity of CTE formation to 1.80 ± 0.44 nmol/mg protein/min (138%) in the liver, but caused only slight enhancement in the kidney and lung. PB-pretreatment markedly enhanced the activity of CDE formation in the kidney. The authors conclude that cytotoxicity by reductive dehalogenation of halothane is possible not only in the liver but also in the kidney with PB-pretreatment. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This study was supported in part by a Research Grant from the Japanese Ministry of Education, Science and Culture. |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
2086561 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
115 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 39,
号 4,
p. 115-118,
発行日 1990-12
|
| 旧ID |
38087 |
HiroshimaJMedSci_39_115.pdf (389.8 KB)
