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The Effect of Timing on Gliclazide Absorption and Action
https://hiroshima.repo.nii.ac.jp/records/2013249
https://hiroshima.repo.nii.ac.jp/records/20132496ccea1c4-0def-4bd0-b09f-945aa86b216f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_39_7.pdf (230.4 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | The Effect of Timing on Gliclazide Absorption and Action | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Ishibashi, Fukashi
× Ishibashi, Fukashi
× Takashina, Seiryo
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Gliclazide | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Pharmacokinetics | |||||||||
| 主題 | ||||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Influence of food | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 490 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | In this study we tried to determine when in relation to meals gliclazide should be taken for optimum hypoglycemic action. Eight non-insulin-dependent diabetics participated in this study during hospitalization for glycemic control. After stabilization of glycemic control on gliclazide, they took a 40 mg tablet of gliclazide either 30 minutes before, immediately before, or immediately after breakfast on 3 consecutive days. We then determined serum gliclazide, glucose and IRI levels at 30-minutes intervals beginning 30 minutes before breakfast and continuing until 2 hours after breakfast. Gliclazide taken 30 minutes before breakfast increased in serum concentration before the meal-induced hyperglycemia, but that taken just before or just after breakfast was poorly absorbed and showed smaller and greatly delayed peaks. When taken 30 minutes before breakfast, gliclazide produced a peak of IRI 30 minutes after the meal; taken immediately before or after, it took twice to three times as long to produce an IRI peak. Postprandial hyperglycemia remained pronounced for a relatively long time when the drug was taken immediately before or after the meal. Based upon the experimental evidence we propose the tentative recommendation that gliclazide is best taken 30 minutes before breakfast. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Hiroshima University Medical Press | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | PMID | |||||||||
| 関連識別子 | 2373640 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 0018-2052 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00664312 | |||||||||
| 開始ページ | ||||||||||
| 開始ページ | 7 | |||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 39, 号 1, p. 7-9, 発行日 1990-03 |
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| 旧ID | 38031 | |||||||||
