| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Biological Activities of Ganglion Extracts from a Prosobranch Mollusc, Fusinus ferrugineus |
|
言語 |
en |
| 作成者 |
Kanda, Tomoko
Takabatake, Ikuo
Fujisawa, Yuko
Ikeda, Tetsuya
Muneoka, Yojiro
Kobayashi, Makoto
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Bioactivity |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Ganglion extract |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Neuropeptide |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Mollusc |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Acetone extract of the ganglia of Fusinus ferrugineus was applied to C-18 cartridges, and the flowthrough and retained materials were bioassayed on the radula retractor muscle of the animal. The flowthrough was found to have a potent contractile action and the retained material a potent contraction-inhibiting action in addition to a weak contractile action. The retained material was then applied to a column (2.6 × 40 cm) of Sephadex G-15. Fractions of 4 ml each were collected, and their activities were assayed on twitch contractions of the radula retractor. Three peaks (E1, E 2 and E3) of contraction-potentiating activity and one peak (I) of contraction-inhibiting activity were obtained. The maximum activities of peaks E 1, E 2 and E3 were found at fractions 22, 44 and 50, respectively. The maximum activity of peak I was found at fractions 28-30. All of the activities of these peaks were destroyed by incubating the fractions with the peptidase subtilisin, suggesting that the active substances in the peaks are peptides. Using some kinds of molluscan muscles, the actions of the substances were examined in greater detail. The results suggest that peak E1 may contain a novel excitatory peptide whose molecular weight is more than 1,000, and that peaks E2 and E3 may contain FMRFamide-related peptides. It is also suggested that peak I may contain two or more myomodulin-CARP-related inhibitory peptides. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by the Grant-in-Aid for General Scientific Research from the Ministry of Education, Science and Culture of Japan. |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
2584053 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
109 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 38,
号 3,
p. 109-116,
発行日 1989-09
|
| 旧ID |
38115 |
HiroshimaJMedSci_38_109.pdf (507.6 KB)
