| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Preventive Effect of Pirenzepine on Atrophic Erosive Gastritis in Rats |
|
言語 |
en |
| 作成者 |
Kishimoto, Shinya
Kobuke, Keiji
Kobayashi, Hirofumi
Kato, Reiko
Kajiyama, Goro
Miyoshi, Akima
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Experimental gastritis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Pirenzepine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Prevention |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The preventive effect of pirenzepine on atrophic erosive gastritis induced experimentally after long exposure of the gastric mucosa in rats to sodium taurocholate (TCA) described. Gastritis was produced in male Wistar rats by giving drinking water ad libitum containing 5 mM TCA for 11 months (Group T). Preventive effect of pirenzepine was designed by giving powder meal containing 100 mg/kg of pirenzepine with TCA-containing drinking water for 11 months (Group P). Rats were also raised with the standard powder meal which is the same as in other two groups but without the agent for 11 months (Group N). The parameters employed in the present study for atrophic erosive gastritis are mucosal surface injury (erosion), reduction of parietal cells per unit area, inflammatory cell infiltration, decreased mucosal thickness and proliferation of collagenous fiber. Significant decrease in the length of total erosions and in the number of ulcers was present in rats with Group P when compared to those in Group T. The mucosal thickness and the number of parietal cells in Group P were not different from those in Group N. Fibrotic proliferation and cyst formation were significantly decreased in Group P when compared to those in Group T. These data indicate that pirenzepine has a preventive effect on the development of atrophic erosive gastritis by TCA in rats. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
3248946 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
119 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 37,
号 3,
p. 119-125,
発行日 1988-09
|
| 旧ID |
38156 |
HiroshimaJMedSci_37_119.pdf (1.0 MB)
