| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Interaction between Epidermal Growth Factor and Gastrin on DNA Synthesis of the Gastrointestinal Mucosa in Rats |
|
言語 |
en |
| 作成者 |
Yasui, Wataru
Sumiyoshi, Hiromichi
Oda, Noriko
Miyamori, Shinji
Kameda, Takashi
Takekura, Naoki
Takanashi, Atsushi
Tahara, Eiichi
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Human epidermal growth factor |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
DNA synthesis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Gastrointestinal mucosa |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Interaction between epidermal growth factor (EGF) and gastrin on DNA synthesis of the rat gastrointestinal tract was examined. Fasted male rats were divided into four groups and injected with 10 μg/kg human EGF, 300 μg/kg pentagastrin, human EGF plus pentagastrin and saline (control), respectively. The animals were sacrificed 8 or 16 hr thereafter and the incorporation of [3H]thymidine into the gastrointestinal mucosa was measured. Human EGF increased DNA synthesis of the fundus, antrum and cecum, while pentagastrin stimulated that of the fundus, duodenum, ileum and proximal colon. Synchronous administration of these peptides also stimulated DNA synthesis of the fundus, antrum and cecum. However, in the ileum and proximal colon, DNA synthesis stimulated by pentagastrin was suppressed by the administration of both agents synchronously. These data suggest that these growth factors regulate the growth of gastrointestinal tract with complex interactions. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by Grant-in Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan (59010074, 60010075). |
| 出版者 |
|
|
出版者 |
Hiroshima University Medical Press |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
3261721 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
1 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 37,
号 1,
p. 1-6,
発行日 1988-03
|
| 旧ID |
38136 |
HiroshimaJMedSci_37_1.pdf (550.2 KB)
