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Relaxing and Inhibitory Actions of Pedal Ganglion Extracts on the Anterior Byssus Retractor Muscle of Mytilus
https://hiroshima.repo.nii.ac.jp/records/2013117
https://hiroshima.repo.nii.ac.jp/records/2013117ffc2b20a-c492-4186-9f39-39df004471c2
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_35_397.pdf (689.3 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Relaxing and Inhibitory Actions of Pedal Ganglion Extracts on the Anterior Byssus Retractor Muscle of Mytilus | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
HIRATA, Tatsumi
× HIRATA, Tatsumi
× KAWAHARA, Akira
× MUNEOKA, Yojiro
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| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Ganglion extract | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Biological action | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Catch muscle | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Pedal ganglion homogenates from the bivalve, Mytilus edulis, were subjected to gel filtration and the biological activities of the extracts were assayed on the ABRM of the mussel. The extracts resolved into a catch-relaxing peak and a contraction-inhibiting peak of activities. Relaxation of ACh-induced catch tension in the ABRM by catch-relaxing peak was not affected by pretreatment of the muscle with 10^-5 M FMRFamide, suggesting that the active principle of the peak is not FMRFamide. The relaxation was blocked by 5 x 10^-4 M mersalyl, which suggests that the active substance is neither dopamine nor octopamine. The relaxation was markedly depressed after the muscle had been denervated by treating it with KCl-EGTA solution, suggesting that the substance is not serotonin and that it relaxes the catch tension acting on intramuscular relaxing nerve elements. The relaxing activity of the peak was destroyed by incubating it with a protease, subtilisin. Thus, the active substance in the peak seems to be a peptide which acts presynaptically to increase the release of relaxing transmitter serotonin. The contraction-inhibiting peak also lost its activity when incubated with subtilisin, suggesting that the inhibitory substance in the peak is also a peptide. The substance inhibited not only phasic contraction by repetitive electrical stimulation but also ACh contraction and FMRFamide contraction, which suggests that it acts directly on muscle fibres to inhibit the contractions. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 3570848 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00664312 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 397 | |||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 35, 号 4, p. 397-402, 発行日 1986-12 |
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| 旧ID | 49948 | |||||||||||
