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Depression of Luminol-Enhanced Chemiluminescence of Guinea Pig Polymorphonuclear Leukocytes by Influenza Virus with Special Reference to Neuraminidase
https://hiroshima.repo.nii.ac.jp/records/2013007
https://hiroshima.repo.nii.ac.jp/records/2013007b005b36d-614d-41c9-88fa-de49cd4562b4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_34_81.pdf (769.6 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Depression of Luminol-Enhanced Chemiluminescence of Guinea Pig Polymorphonuclear Leukocytes by Influenza Virus with Special Reference to Neuraminidase | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
KIYOTANI, Katsuhiro
× KIYOTANI, Katsuhiro
× TAKEI, Naomi
× MATSUO, Yoshiyasu
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| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Luminol-enhanced chemiluminescence | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Influenza virus | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Guinea pig PMNL | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Neuraminidase | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Effect of influenza virus on luminol-enhanced chemiluminescent response of guinea pig polymorphonuclear leukocytes (PMNL) was investigated in order to elucidate a possible mechanism by which influenza virus modified the oxidative metabolism of PMNL. Influenza viruses, strains A/USSR/92/77(H1N1) and B/Kanagawa/3/76(B), rapidly stimulated oxidative burst of resting PMNL and the peak chemiluminescence initiated by them was 5 to 15 times as high as that induced by PBS(—), while the peak chemiluminescent response induced by phorbol myristate acetate (PMA) delayed and the values were counted to be approximately 40% of that of PBS(—)-incubated cells. No significant changes were observed in both activities to enhance chemiluminescent response of resting PMNL and to depress PMA-induced chemiluminescent response when influenza virus with heatinactivated neuraminidase activity at 56°C for 20 min was used. Moreover, neither initiation of oxidative burst of PMNL nor depression of PMA-induced chemiluminescent response was observed with purified neuraminidase extracted from influenza virus. It seems likely that viral neuraminidase is at least not a critical component to modify the oxidative metabolism of guinea pig PMNL. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 4019245 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00664312 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 81 | |||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 34, 号 1, p. 81-86, 発行日 1985-03 |
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| 旧ID | 49838 | |||||||||||
