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アイテム
ラット心移植における hyperacute rejection モデルの作製
https://hiroshima.repo.nii.ac.jp/records/2012944
https://hiroshima.repo.nii.ac.jp/records/20129440bde3752-9c9d-43a8-9bfc-8627bf5aedfc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_33_251.pdf (484.8 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | An Experimental Model for Hyperacute Rejection in Inbred Rat Cardiac Transplantation : Correlation Cardiac Graft Survival Time and Anti T-Cell Warm Cytotoxic Antibody Titer | |||||||||||
| 言語 | en | |||||||||||
| タイトル | ||||||||||||
| タイトル | ラット心移植における hyperacute rejection モデルの作製 | |||||||||||
| 言語 | ja | |||||||||||
| 作成者 |
Dohi, Kiyohiko
× Dohi, Kiyohiko
× Tabe, Yasuji
× Ezaki, Haruo
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| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Hyperacute rejection | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Active immunization | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Cardiac transplantation | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Hyper immunization | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Anti T-cell warm cytotoxic antibody | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Using genetically homogeneous inbred ACI and Fischer rats, the author has conducted active immunization with the skin and lymphoid cells from ACI rat to Fischer rat and succeeded in making an experimental model that unfailingly causes hyperacute rejection, which has heretofore been considered to be extremely difficult. Semipermanent survival was gained with syngenetic graft. With allograft, acute rejection of the cardiac graft took place in 8.1±1.4 days. On heart transplantation from ACI to Fischer recipients sensitized by skin graft from ACI and two times active immunization with spleen lymphoid cells from ACI, accelerate rejection occurred in 60.8±32.7 hr. On transplantation of ACI heart in Fischer recipients subjected to skin graft and five times or more hyperimmunization with spleen lymphoid cells, hyperacute rejection of the cardiac graft occurred in all cases in 2.2 ± 3.5 hr. As regards active immunization and anti-T cell warm cytotoxic antibody formation, skin graft followed by five times active immunization gave a titer of 2^8.11 ±1.5 and the antibody formation reached a plateau. Anti-T cell warm cytotoxic antibody and survival time of the cardiac graft showed the following correlation. log10 (y) = －0.054x+2.113 (x<3.622) log10 (y) = －0.4742x+3.4778 (x>3.622) C = 3.622 was recognized. The anti-T cell warm cytotoxic antibodies were found to be decreased with a significant difference (P<0.01) after hyperacute rejection. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 6384146 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00664312 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 251 | |||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 33, 号 2, p. 251-257, 発行日 1984-06 |
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| 旧ID | 38209 | |||||||||||
