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アイテム
慢性肉芽腫症患児の多核白血球の膜電位変化
https://hiroshima.repo.nii.ac.jp/records/2012934
https://hiroshima.repo.nii.ac.jp/records/2012934bbd50b03-9ff6-43b4-a20d-456485de234a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_33_173.pdf (338.8 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Membrane Potential Changes in Polymorphonuclear Leukocytes of Patients with Chronic Granulomatous Disease | |||||||||||
| 言語 | en | |||||||||||
| タイトル | ||||||||||||
| タイトル | 慢性肉芽腫症患児の多核白血球の膜電位変化 | |||||||||||
| 言語 | ja | |||||||||||
| 作成者 |
Matsuura, Ryoji
× Matsuura, Ryoji
× Kobayashi, Masao
× Usui, Tomofusa
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| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Chronic granulomatous disease | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | Depolarization | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | NADPH oxidase | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 490 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | The activation of NADPH oxidase on the plasma membranes of polymorphonuclear leukocytes (PMNL) follows the change of membrane potential. It is thought that the activation of NADPH oxidase is disturbed in the PMNL of patients with chronic granulomatous disease (CGD). The change of membrane potential was examined in the PMNL of normal subjects and patients with CGD, with a lipophilic probe, di-O-C5(3). There was a disturbance in phorbol myristate acetate (PMA) and formyl-methionyl-leucyl-phenylalanine (FMLP)-induced depolarization but not in Ca ionophore A23187-induced depolarization of the PMNL of patients with CGD. A23187-induced depolarization was not always associated with O2- release in normal PMNL. A23187 differed from PMA and FMLP in several aspects of its action on depolarization. It is concluded that only depolarization which couples with O2- release is disturbed in the PMNL of patients with CGD. Increase in extracellular potassium (K) caused PMNL of both normal subjects and CGD patients to depolarize but made them not to release O2-. Otherwise, A23187-induced depolarization was disturbed in PMNL of CGD patients with higher extracellular K concentrations. These findings help to confirm the theory that K efflux on the plasma membrane is disturbed in the PMNL of patients with CGD. | |||||||||||
| 言語 | en | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Other | |||||||||||
| 内容記述 | This work has been supported in part by Grants-in-Aid for Scientific Research (Project Nos. 544050, 448227) from the Ministry of Education, Science and Culture of Japan and a Grant-in-Aid from the Japan Medical Research Foundation. | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | PMID | |||||||||||
| 関連識別子 | 6480382 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00664312 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 173 | |||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 33, 号 2, p. 173-177, 発行日 1984-06 |
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| 旧ID | 38199 | |||||||||||
