| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Micronuclei and Chromosome Aberrations Found 1n Bone Marrow Cells and Lymphocytes from Thorotrast Patients and Atomic Bomb Survivors |
|
言語 |
en |
| タイトル |
|
|
タイトル |
トロトラスト症患者と原爆被爆者の骨髄細胞、リンパ球にみられた血球小核と染色体異常 |
|
言語 |
ja |
| 作成者 |
Tanaka, Kimio
Izumi, Takaki
Ohkita, Takeshi
Kamada, Nanao
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Micronucleus |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Chromosome aberration |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Atomic bomb survivors |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Thorotrast patients |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
As two cytogenetic parameters of radiation exposure, the frequency of micronucleus in erythroblasts, lymphocytes and red cells (Howell-Jolly body) as well as chromosome aberrations in bone marrow cells and in lymphocytes were studied in 24 thorotrast patients and in 32 atomic bomb (A-bomb) survivors who were exposed within one kilometer from the Hiroshima hypocenter. The incidence of both micronucleus and chromosome aberrations in these two exposed groups were significantly higher than that in non-exposed controls. So that these two parameters are useful guide for evaluating the residual effects of radiation, especially on hematopoietic cells. Because of its simple procedures, micronucleus test is also helpful as screening for prediction of chromosome aberrations. The characteristics of lymphocyte chromosome aberrations differed considerably between thorotrast patients and A-bomb survivors; the incidence of unstable type aberrations and intracellular complexity of chromosome aberrations were much higher in the former group. The incidence of micronucleus in erythroblasts and lymphocytes was also higher in thorotrast patients. Such differences are attributable to the differences in the radiation quality (α-ray or γ-ray + neutron) and in the mode of exposure (persistent or single) of these two groups. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Health and Welfare and the Ministry of Education, Science and Culture. |
| 出版者 |
|
|
出版者 |
Hiroshima University School of Medicine |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
6480366 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
101 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 33,
号 1,
p. 101-111,
発行日 1984-03
|
| 旧ID |
38178 |
HiroshimaJMedSci_33_101.pdf (1.1 MB)
