| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
The Influence of the Autonomic Nervous System on the Onset of Stress Ulcers : Mainly on the Changes of Biogenic Amine Contents in Brain and Stomach in Cold Restrained Rats |
|
言語 |
en |
| タイトル |
|
|
タイトル |
ストレス潰瘍発生におよぼす自律神経系の影響 : 寒冷拘束ラットにおける脳内並びに胃壁内アミンの変動を中心として |
|
言語 |
ja |
| 作成者 |
Ito, Nobuaki
Kodama, Motomu
Ogawa, Yoshiteru
Kodama, Osamu
Takeuchi, Hitoshi
Tanaka, Tsuneo
Seikoh, Rokuro
Harada, Mitsuo
Ezaki, Haruo
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Stress ulcer |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Autonomic nervous system |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Biogenic amines |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Acute gastroduodenal ulcers are frequently induced by the stress of various type. With a view to examining the influence of the autonomic nervous system on the mechanism of onset of stress ulcers, splanchnicotomy or vagotomy was performed in rats and loaded cold restraint stress for 120 minutes. Subsequently, the contents of biogenic amines in brain and stomach were determined. Further observations on the pH value of the gastric jujce and the microvasculature of the gastric mucosa were made, and the following results were obtained. 1. The incidence of gastric ulcers in the control and splanchnicotomized group markedly increased in 60 minutes after stress, whereas in the vagotomized group, it did not show an increase even 120 minutes. 2. As for amines in brain, NA content significantly decreased in 60 minutes, while 5-HT content increased significantly. These changes were fixed, regardless of the cutting of the autonomic nerve or not. 3. Regarding amines in stomach, HA and 5-HT content significantly decreased in the control and splanchnicotomized group. 4. The pH value in gastric juice did not decreased significantly with time up to 120 minutes, in all groups. 5. Impairment on microcirculation in gastric mucosa were suggested in the control and splanchnicotomized group after stress. Judging from these findings, it was assumed that, for the onset of stress ulcers, NA and 5-HT in brain were associated, whereas in stomach, HA and 5-HT isolated by the vagotonia, rather than the NA isolated by the sympathicotonia, were associated. It was further presumed that stress ulcers are caused by the impairments on the microcirculation on gastric mucosa due to the isolation of HA and 5-HT, rather than the increase in the acidity of gastric juice. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Hiroshima University School of Medicine |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
6643110 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0018-2052 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00664312 |
| 開始ページ |
|
|
開始ページ |
329 |
| 書誌情報 |
Hiroshima Journal of Medical Sciences
Hiroshima Journal of Medical Sciences
巻 32,
号 3,
p. 329-339,
発行日 1983-09
|
| 旧ID |
38328 |
HiroshimaJMedSci_32_329.pdf (1.2 MB)
