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モルモット腹腔マクロファージのリパーゼ活性とマイコバクテリアルリパーゼインヒビター
https://hiroshima.repo.nii.ac.jp/records/2012876
https://hiroshima.repo.nii.ac.jp/records/2012876649e34e3-f452-48d8-a13b-d378b9657c4a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_32_267.pdf (336.1 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Lipase Activity of Guinea Pig Peritoneal Macrophages and Mycobacterial Lipase Inhibitor | |||||||||||||
| 言語 | en | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | モルモット腹腔マクロファージのリパーゼ活性とマイコバクテリアルリパーゼインヒビター | |||||||||||||
| 言語 | ja | |||||||||||||
| 作成者 |
Kiyotani, Katsuhiro
× Kiyotani, Katsuhiro
× Tasaka, Hiromichi
× Tsukiyama, Fumiaki
× Matsuo, Yoshiyasu
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| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Lipase | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | GP-PMφs | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Mycobacterial lipase inhibitor | |||||||||||||
| 主題 | ||||||||||||||
| 主題Scheme | NDC | |||||||||||||
| 主題 | 490 | |||||||||||||
| 内容記述 | ||||||||||||||
| 内容記述 | The interaction of mycobacterial lipase inhibitor (MLI), isolated from culture supernatant fluid of Mycobacterium tuberculosis strain H37Rv, and lipase from guinea pig peritoneal macrophages (GP-PMφs) was investigated fluorimetrically by the modified lipase assay system which had previously been proposed. Two peaks of lipase activity were observed in the enzyme preparation from GPPMφs. The activity of MLI against lipase from GP-PMφs was significantly high at acidic pH less than 5.0, and the pattern of inhibition was non-competitive. Two types of lipase were isolated from the enzyme solution prepared from GPPMφs by an ion-exchange chromatography on a DEAE-Sepharose column. One of these acted only at pH 4.5 and was considered to be a lysosomal acid lipase, but another showed the activity at both pH 4.5 and 7.0. The former was four times more sensitive to the activity of MLI than the latter as well as the crude enzyme preparation. | |||||||||||||
| 言語 | en | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
| 関連情報 | ||||||||||||||
| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | 6417063 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0018-2052 | |||||||||||||
| 収録物識別子 | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA00664312 | |||||||||||||
| 開始ページ | ||||||||||||||
| 開始ページ | 267 | |||||||||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 32, 号 3, p. 267-271, 発行日 1983-09 |
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| 旧ID | 38317 | |||||||||||||
