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Anti-microtubular agent のアロキサンによるインスリン分泌およびブドウ糖によるインスリン分泌阻害に及ぼす影響
https://hiroshima.repo.nii.ac.jp/records/2012818
https://hiroshima.repo.nii.ac.jp/records/2012818a406fd31-2a94-4296-8947-5782c20698fa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_31_91.pdf (372.3 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Effects of Anti-Microtubular Agents on Alloxan Stimulation and Inhibition of Glucose-Induced Insulin Release in Vitro | |||||||
| 言語 | en | |||||||
| タイトル | ||||||||
| タイトル | Anti-microtubular agent のアロキサンによるインスリン分泌およびブドウ糖によるインスリン分泌阻害に及ぼす影響 | |||||||
| 言語 | ja | |||||||
| 作成者 |
Ishibashi, Fukashi
× Ishibashi, Fukashi
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Alloxan | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Anti-microtubular agents | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Glucose-induced insulin release | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Pancreatic islets | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | The effect of various anti-microtubular agents on alloxan stimulation and inhibition of a subsequent glucose-induced insulin release was investigated using in vitro incubation and perifusion of rat isolated islets of Langerhans. Five minute exposure of islets to alloxan (20 mg/dl) induced a transient burst of insulin release which was eliminated by the pretreatment of islets by heavy water (D2O) or colchicine (10-3 M) and concomitant presence of them with alloxan. However, vincristine (10-4 M) did not affect alloxan actions. A brief exposure .of islets to alloxan completely inhibited a subsequent glucose (16.7 mM)-induced insulin release. The pretreatment of islets with D2O or colchicine prevented alloxan inhibition of insulin release, whereas vincristine did not demonstrate such an action. Because the transport of pyrimidine was completely inhibited by anti-microtubular agents, it seems likely that the transport of alloxan (2, 4, 5, 6-tetraoxypyrimidine, 5, 6-dioxyuracil) into the B-cell is impaired by these agents. Otherwise, anti-microtubular agents reduced the generation of highly reactive oxygen-containing free radicals from alloxan, which inhibits the glucose-induced insulin release. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 6752103 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 91 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 31, 号 2, p. 91-95, 発行日 1982-06-10 |
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| 旧ID | 38380 | |||||||
