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ラットにおける実験的大腸腫瘍の研究 : 第一報 1,2-ジメチルヒドラジン誘発大腸腫瘍のラット系統差について
https://hiroshima.repo.nii.ac.jp/records/2012805
https://hiroshima.repo.nii.ac.jp/records/20128052ff92af2-b5b1-4f2f-b922-0cd69a4774cc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
HiroshimaJMedSci_30_355.pdf (4.3 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | STUDIES ON EXPERIMENTAL COLON TUMORIGENESIS IN RATS : 1. STRAIN DIFFERENCES IN INCIDENCE, LOCATION AND TUMOR TYPES OF 1, 2-DIMETHYLHYDRAZINE-INDUCED TUMORS | |||||||
| 言語 | en | |||||||
| タイトル | ||||||||
| タイトル | ラットにおける実験的大腸腫瘍の研究 : 第一報 1,2-ジメチルヒドラジン誘発大腸腫瘍のラット系統差について | |||||||
| 言語 | ja | |||||||
| 作成者 |
Naito, Yukiko
× Naito, Yukiko
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | Susceptibility to 1, 2-dimethylhydrazine (DMH) was comparatively studied using two rats strains, Wistar-Furth substrain (WF/O) rats derived from the family with a high incidence of spontaneous colon tumor, and Long-Evans (LE) rats. Ten-week-old rats of both sexes were injected with DMH (20 mg/kg body weight) weekly for 20 weeks, and sacrificed at the 10th, 15th, 20th, and 25th week after the last injection. LE rats developed colon tumors more frequently in terms of crude incidence (21/21) (p<0.01) and the number of tumors per rat (6.1) (p<0.05) than those (17/25, 2.5) in WF/O rats. The predilection site of induced tumors was the descending colon in LE rats (59/128), in which adenomas were prevailing, where only a small number of tumors were found in WF/O rats (8/42). In both strains ascending colon was far more crowded with poorly differentiated adenocarcinoma than other sites of the colon (8/19, 14/34). It is likely that a resistant rat strain (WF/O) for DMH carcinogenesis has emerged from a parent rat strain prone to develop colonic tumors spontaneously. | |||||||
| 言語 | en | |||||||
| 出版者 | ||||||||
| 出版者 | Hiroshima University School of Medicine | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | departmental bulletin paper | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | VoR | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | PMID | |||||||
| 関連識別子 | 6765685 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 0018-2052 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | NCID | |||||||
| 収録物識別子 | AA00664312 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 355 | |||||||
| 書誌情報 |
Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 巻 30, 号 4, p. 355, 発行日 1981-12-10 |
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| 旧ID | 38410 | |||||||
