| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2019-09-18 |
| タイトル |
|
|
タイトル |
Maternal estrogen controls retinoic acid metabolism and signaling in early vertebrate development |
|
言語 |
en |
| 作成者 |
Nishinaga, Masanori
Onizuka, Yuh-ichi
Hanafusa, Takahiro
Nomiyama, Kei-ichi
Watanabe, Daisuke
Kinashi, Toshifumi
Murashige, Toshiaki
Kunishi, Munehiro
Hori-e, Ryota
Hayashida, Yasufumi
Yamashita, Ichirou
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2019 by Authors |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
maternal estrogen |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
estrogen receptor |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
retinoic acid |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
hindbrain |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
anterior-posterior axis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
vasculogenesis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
medakafish |
| 内容記述 |
|
|
内容記述 |
Fertilized eggs of lower vertebrates contain substantial amounts of steroidal hormones such as estrogen transferred from mother during oogenesis. However, molecular roles for maternal estrogen in the early embryonic development are largely unknown. Here we show that maternal estrogen and estrogen receptor-α modulate retinoic acid (RA) metabolism and RA-responsive gene expression in medaka embryos. Treatments with excess estradiol, an anti-estrogen (tamoxifen), overexpression or knockdown of estrogen receptor-α (ERα) resulted in misregulation of RA-related gene expression such as raldh2 (retinalaldehyde dehydrogenase), cyp26a1 (RA hydroxylase), fgf8 (fibroblast growth factor), rarα (RA receptor-α), and ahr1 (aryl hydrocarbon receptor). We propose that maternal estrogen/ERα plays a critical role in the feedback control of in vivo level of RA and that it also activates RA signaling for the development of hindbrain and vasculatures. This is the first report demonstrating that maternal estrogen supports successful embryonic development by controlling RA metabolism and signaling in early vertebrate embryos. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan. |
| 日付 |
|
|
日付 |
2019-09-18 |
|
日付タイプ |
Created |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_1843 |
|
資源タイプ |
other |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 開始ページ |
|
|
開始ページ |
1 |
| 書誌情報 |
p. 1-87
|
| 旧ID |
48177 |
| 備考 |
未発表原稿 |
Maternal estrogen controls retinoic acid metabolism and signaling in early vertebrate development.pdf (4.4 MB)
