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A model for how fission yeast cells scale their size with ploidy
https://hiroshima.repo.nii.ac.jp/records/2011746
https://hiroshima.repo.nii.ac.jp/records/201174635db28ee-aa02-4d3e-b101-3ab96a473729
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
A model for how fission yeast cells scale their size with ploidy.pdf (3.0 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2020-04-28 | |||||||
| タイトル | ||||||||
| タイトル | A model for how fission yeast cells scale their size with ploidy | |||||||
| 言語 | en | |||||||
| 作成者 |
Yamashita, Ichirou
× Yamashita, Ichirou
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利情報 | ||||||||
| 権利情報 | © Copyright by Ichiro Yamashita 2020 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | actin | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | cdc25 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | nim1 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | ploidy | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | scaling | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | wee1 | |||||||
| 内容記述 | ||||||||
| 内容記述 | It has long been known that eukaryotic cells with more DNA content are larger in cell size. However, no molecular mechanisms for this universal rule have been given. In the fission yeast Schizosaccharomyces pombe, diploid cells grow faster at 1.5-fold rate than haploid cells during the same cycle time. Here I discovered that cell division genes control not only cell growth or cell extension rate (CER) but also cycle time dose-dependently in diploid cells. These genes are well-known regulators for Cdc2, a conserved master regulator of eukaryotic cell cycle, such as inhibitors (wee1+ and pom1+) and activators (cdc25+ and nim1+). Actin content and its dynamics between monomer and polymer forms also control CER and cycle time through nuclear accumulation of Wee1 and Cdc25. Remarkably, doubling these genes in haploids reproduced CER of diploids. I propose a model in which regulatory cascades for Cdc2 activity govern the cell-size scaling with ploidy. | |||||||
| 言語 | en | |||||||
| 日付 | ||||||||
| 日付 | 2020-04-28 | |||||||
| 日付タイプ | Created | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||||
| 資源タイプ | other | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AO | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||
| 開始ページ | ||||||||
| 開始ページ | 1 | |||||||
| 書誌情報 |
p. 1-65 |
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| 旧ID | 49093 | |||||||
| 備考 | 未発表原稿 | |||||||
