| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Possible therapeutic effect of lipid supplementation on neurotoxicity in liver transplant recipients |
|
言語 |
en |
| 作成者 |
Ide, Kentaro
Ohdan, Hideki
Tahara, Hiroyuki
Ishiyama, Kohei
Shishida, Masayuki
Irei, Toshimitsu
Ohira, Masahiro
Tashiro, Hirotaka
Itamoto, Toshiyuki
Asahara, Toshimasa
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2007 Blackwell Publishing. The definitive version is available at www.blackwell-synergy.com |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cholesterol |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
living donor liver transplantation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
neurotoxicity |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
soybean oil |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Neurotoxicity represents a serious complication following liver transplantation and may be evoked by various perioperative factors or develop due to toxicity of immunosuppresion. The symptoms of neurotoxicity associated with calcineurin inhibitors (CNIs) may be reversed by discontinuing or reducing the dose of CNIs; however, this may increase the risk of rejection. To address this issue, we examined 45 adult living donor liver transplant recipients. At the time of neurotoxicity diagnosis, serum cholesterol values were significantly lower in the patients with neurotoxicity than in those without neurotoxicity. Based on our hypothesis that lipid supplementation prevents lipophilic CNIs from crossing the blood-brain barrier, soybean oil was administered to 5 patients with neurotoxicity. In all these patients, the neurological symptoms improved without discontinuing or reducing the dose of CNIs. This use of this therapy may help in avoiding insufficient immunosuppressive therapy because neither dose reduction nor substitution of CNIs would be then required. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Blackwell Publishing |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/j.1432-2277.2007.00487.x |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1111/j.1432-2277.2007.00487.x |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0934-0874 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10762158 |
| 開始ページ |
|
|
開始ページ |
632 |
| 書誌情報 |
Transplant International
Transplant International
巻 20,
号 7,
p. 632-635,
発行日 2007-07
|
| 旧ID |
20740 |
TransplInt_20-7_632.pdf (64.1 KB)
