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Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice

https://hiroshima.repo.nii.ac.jp/records/2008791
https://hiroshima.repo.nii.ac.jp/records/2008791
3a78142f-bcf4-405d-8d75-75e7109026d3
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SciRep_6_20157.pdf SciRep_6_20157.pdf (4.5 MB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル Involvement of resistin-like molecule β in the development of methionine-choline deficient diet-induced non-alcoholic steatohepatitis in mice
言語 en
作成者 Okubo, Hirofumi

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Kushiyama, Akifumi

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Sakoda, Hideyuki

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Nakatsu, Yusuke

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Iizuka, Masaki

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Taki , Naoyuki

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Fujishiro, Midori

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Fukushima, Toshiaki

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Kamata, Hideaki

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Nagamachi, Akiko

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Inaba, Toshiya

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Nishimura, Fusanori

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Katagiri, Hideki

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Asahara, Takashi

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Yoshida, Yasuto

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Chonan, Osamu

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Encinas, Jeffery

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Asano, Tomoichiro

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
内容記述
内容記述 Resistin-like molecule β (RELMβ) reportedly has multiple functions including local immune responses in the gut. In this study, we investigated the possible contribution of RELMβ to non-alcoholic steatohepatitis (NASH) development. First, RELMβ knock-out (KO) mice were shown to be resistant to methionine-choline deficient (MCD) diet-induced NASH development. Since it was newly revealed that Kupffer cells in the liver express RELMβ and that RELMβ expression levels in the colon and the numbers of RELMβ-positive Kupffer cells were both increased in this model, we carried out further experiments using radiation chimeras between wild-type and RELMβ-KO mice to distinguish between the contributions of RELMβ in these two organs. These experiments revealed the requirement of RELMβ in both organs for full manifestation of NASH, while deletion of each one alone attenuated the development of NASH with reduced serum lipopolysaccharide (LPS) levels. The higher proportion of lactic acid bacteria in the gut microbiota of RELMβ-KO than in that of wild-type mice may be one of the mechanisms underlying the lower serum LPS level the former. These data suggest the contribution of increases in RELMβ in the gut and Kupffer cells to NASH development, raising the possibility of RELMβ being a novel therapeutic target for NASH.
言語 en
出版者
出版者 Nature Publishing Group
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/srep20157
関連情報
識別子タイプ PMID
関連識別子 26818807
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 2045-2322
開始ページ
開始ページ 20157
書誌情報 Scientific Reports
Scientific Reports

巻 6, p. 20157, 発行日 2016-01-28
旧ID 48635
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