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KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome

https://hiroshima.repo.nii.ac.jp/records/2008754
https://hiroshima.repo.nii.ac.jp/records/2008754
bef1de7e-c51f-405c-af07-c512dcca68fd
名前 / ファイル ライセンス アクション
RespirRes_12_32.pdf RespirRes_12_32.pdf (283.6 KB)
Item type デフォルトアイテムタイプ_(フル)(1)
公開日 2023-03-18
タイトル
タイトル KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome
言語 en
作成者 Kondo, Tomohiro

× Kondo, Tomohiro

en Kondo, Tomohiro

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Hattori, Noboru

× Hattori, Noboru

en Hattori, Noboru

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Ishikawa, Nobuhisa

× Ishikawa, Nobuhisa

en Ishikawa, Nobuhisa

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Murai, Hiroshi

× Murai, Hiroshi

en Murai, Hiroshi

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Haruta, Yoshinori

× Haruta, Yoshinori

en Haruta, Yoshinori

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Hirohashi, Nobuyuki

× Hirohashi, Nobuyuki

en Hirohashi, Nobuyuki

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Tanigawa, Koichi

× Tanigawa, Koichi

en Tanigawa, Koichi

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Kohno, Nobuoki

× Kohno, Nobuoki

en Kohno, Nobuoki

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アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
権利情報
権利情報 Copyright (c) 2011 Kondo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
主題
主題Scheme NDC
主題 490
内容記述
内容記述 Background: KL-6 is a mucin-like glycoprotein expressed on the surface of alveolar type II cells. Elevated concentrations of KL-6 in serum and epithelial lining fluid (ELF) in patients with acute respiratory distress syndrome (ARDS) have been previously reported; however, kinetics and prognostic significance of KL-6 have not been extensively studied. This study was conducted to clarify these points in ARDS patients. Methods: Thirty-two patients with ARDS who received mechanical ventilation under intubation were studied for 28 days. ELF and blood were obtained from each patient at multiple time points after the diagnosis of ARDS. ELF was collected using a bronchoscopic microsampling procedure, and ELF and serum KL-6 concentrations were measured. Results: KL-6 levels in ELF on days 0 to 3 after ARDS diagnosis were significantly higher in nonsurvivors than in survivors, and thereafter, there was no difference in concentrations between the two groups. Serum KL-6 levels did not show statistically significant differences between nonsurvivors and survivors at any time point. When the highest KL-6 levels in ELF and serum sample from each patient were examined, KL-6 levels in both ELF and serum were significantly higher in nonsurvivors than in survivors. The optimal cut-off values were set at 3453 U/mL for ELF and 530 U/mL for serum by receiver operating characteristic (ROC) curve analyses. Patients with KL-6 concentrations in ELF higher than 3453 U/mL or serum concentrations higher than 530 U/mL had significantly lower survival rates up to 90 days after ARDS diagnosis. Conclusions: ELF and serum KL-6 concentrations were found to be good indicators of clinical outcome in ARDS patients. Particularly, KL-6 levels in ELF measured during the early period after the diagnosis were useful for predicting prognosis in ARDS patients.
言語 en
出版者
出版者 BioMed Central
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
出版タイプ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
関連情報
識別子タイプ DOI
関連識別子 10.1186/1465-9921-12-32
関連情報
識別子タイプ DOI
関連識別子 http://dx.doi.org/10.1186/1465-9921-12-32
収録物識別子
収録物識別子タイプ ISSN
収録物識別子 1465-9921
収録物識別子
収録物識別子タイプ NCID
収録物識別子 AA12051434
開始ページ
開始ページ 32
書誌情報 Respiratory Research
Respiratory Research

巻 12, p. 32, 発行日 2011-03-22
旧ID 32032
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