| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Liposome collapse resulting from an allosteric interaction between 2,6‐dimethyl‐β‐cyclodextrins and lipids |
|
言語 |
en |
| 作成者 |
Ikeda, Atsushi
Iwata, Noboru
Hino, Shodai
Mae, Tomoya
Tsuchiya, Yuki
Sugikawa, Kouta
Hirao, Takehiro
Haino, Takeharu
Ohara, Kazuaki
Yamaguchi, Kentaro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
This journal is © The Royal Society of Chemistry 2015 |
| 権利情報 |
|
|
権利情報 |
This is an open access article distributed under the terms of the Creative Commons Attribution 3.0 Unported Licence. |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
430 |
| 内容記述 |
|
|
内容記述 |
Although heptakis(2,6‐di‐O‐methyl)‐β‐cyclodextrin (DMe‐β‐CDx) has been reported to exhibit higher cytotoxicity than many other cyclodextrins because of the way in which it abstracts cholesterols from liposomes, we have identified another reason for its cytotoxicity based on its interaction with lipids. These interactions exhibited nonlinear sigmoidal responses with Hill coefficient values (n) in the range of 3.0‒3.6, which indicated that this phenomenon involves positive allosterism. Furthermore, analysis by mass spectroscopy revealed that the lipid•DMe‐β‐CDx complexes had stoichiometric ratios in the range of 1:1‒1:4. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Electronic supplementary information (ESI) available: Average hydrodynamic diameter values and UV-vis absorption, 1H NMR, NOESY and CSI-MS spectra. See DOI: 10.1039/c5ra14970c |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by a JSPS KAKENHI a Grant‐in‐Aid for Scientific Research (B) (Grant No. 25288037). |
| 出版者 |
|
|
出版者 |
Royal Society of Chemistry |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1039/c5ra14970c |
| 収録物識別子 |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2046-2069 |
| 開始ページ |
|
|
開始ページ |
77746 |
| 書誌情報 |
RSC Advances
RSC Advances
巻 5,
号 95,
p. 77746-77754,
発行日 2015-09-09
|
| 旧ID |
45810 |
RSCAd_5-95_77746.pdf (1.7 MB)
