| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Time course of changes in in vitro sarcoplasmic reticulum Ca2+-handling and Na+-K+-ATPase activity during repetitive contractions |
|
言語 |
en |
| 作成者 |
Mishima, Takaaki
Yamada, Takashi
Sakamoto, Makoto
Sugiyama, Minako
Matsunaga, Satoshi
Wada, Masanobu
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2007 Springer-Verlag |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
muscle fatigue |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
structural modification |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
in vitro measurement |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cation regulation protein |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
oxidative potential |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
460 |
| 内容記述 |
|
|
内容記述 |
Time-dependent changes in sarcoplasmic reticulum (SR) Ca2+-handling and Na+-K+-ATPase activity, as assessed in vitro, were investigated in the superficial (GS) and deep regions (GD) of rat gastrocnemius muscles undergoing short-term (up to 30 min) electrical stimulation. There was a rapid and progressive loss of force output during the first 5 min of stimulation. For GS, significant depressions (P < 0.05) in SR Ca2+-uptake rate and Ca2+-ATPase activity were observed during only the first 1 min. No further reductions occurred with stimulation time. SR Ca2+-release rate was significantly (P < 0.05) decreased at 3 min. For GD, significant reductions (P <0.05) in Ca2+-uptake rate, Ca2+-release rate and Ca2+-ATPase activity were manifested after 3, 5 and 5 min, respectively. A decay in Na+-K+-ATPase activity was found only in 1-min stimulated GD and 30-min stimulated GS. After 30 min, the depressed functions reverted to resting levels in GD but not in GS. The alterations in any variables examined were not parallel with changes in force output. These results suggest that, at least under the conditions used in this study, in vivo disruptions in cation regulation mediated by vigorous contractile activity would be attributable primarily to events other than structural alterations to the respective proteins. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Springer-Verlag |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
関連名称 |
The original version is abailable at www.springerlink.com |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1007/s00424-007-0427-8 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1007/s00424-007-0427-8 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00771833 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0031-6768 |
| 開始ページ |
|
|
開始ページ |
601 |
| 書誌情報 |
Pflügers Archiv : European Journal of Physiology
Pflügers Archiv : European Journal of Physiology
巻 456,
号 3,
p. 601-609,
発行日 2008-06
|
| 旧ID |
23280 |
PA_456_601.pdf (218.5 KB)
